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Cuiqing Ma
Phone number: 0531-88369463
Fax number: 
E-mail: macq@sdu.edu.cn
Title: Professor


Ph.D 1999.09-2003.06 Shandong University Microbiology

Master 1996.09-1999.07 Shandong University Microbiology

Bachelor 1982.09-1986.06 East China University of Science and Technology Biochemical Engineering


1986.7- Shandong University Professor

2004.5-2005.5 German Research Center for Biotechnology Visiting Scholar


1 Metabolic Engineering: Application of synthetic biology and molecular enzyme modification technology to build efficient microbial catalyst.

2 Biorefinery: Production of bulk chemicals and pharmaceutical intermediates through biological method; biological product separation and purification technology.

3 Microbial Physiology and Biochemistry: Mechanisms of microbial metabolism and related key enzymes.


1 National Natural Science Foundation of China (NSFC) (31670041), Research on the elimination mechanism of acetate overflow in Enterobacter cloacae, 2017.01-2020.12

2 National Natural Science Foundation of China (NSFC) (31470164), Investigation of the 2,3-butanediol metabolic mechanism in Pseudomonas putida KT2440, 2015.01-2018.12

3 National Natural Science Foundation of China (NSFC) (31270090), Studies on structure and regulation mechanism of microbial lactate metabolism regulator LldR, 2013.01-2016.12

4 National Natural Science Foundation of China (NSFC) (31170052), A novel NAD-independent L-lactate dehydrogenases in Pseudomonas stutzeri, 2012.01-2015.12

5 Chinese National Program for High Technology Research and Development (2011AA02A207), Biorefinery of chemical polyols based on biomass renewable resources, 2011.09-2015.12


1. Zhang LJ, Liu QY, Ge YS, Li LX, Gao C, Xu P and Ma CQ *, Biotechnological production of acetoin, a biobased platform chemical, from a lignocellulosic resource by metabolically engineered Enterobacter cloacae, Green Chem. 2016, 18: 1560-70 (SCI, IF 8.02)

2. Gao C, Li Z, Zhang LJ, Wang C, Li K, Ma CQ*, Xu P*, An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol, Green Chem. 2015, 17, 804-7 (SCI, IF 8.02)

3. Li LX§, Li K§, Wang Y, Chen C, Xu YQ, Zhang LJ, Han BB, Gao C, Ma CQ*, Xu P*, Metabolic engineering of Enterobacter cloacae for high-yield production of enantiopure (2R,3R)-2,3-butanediol from lignocellulose-derived sugars, Metab. Eng. 2015, 28: 19-27 (SCI, IF 6.767)

4. Gao C, Wang YJ, Zhang YX, Lv M, Dou PP, Xu P, Ma CQ*, NAD-Independent L-lactate dehydrogenase required for L-lactate utilization in Pseudomonas stutzeri A1501, J Bacteriol. 2015, 197(13):2239-47 (SCI, IF 2.808)

5. Xu YQ, Chu HP, Gao C, Tao F, Zhou ZL, Li K, Li LX, Ma CQ*, Xu P*, Systematic metabolic engineering of Escherichia coli for high-yield production of fuel bio-chemical 2,3-butanediol, Metab. Eng. 2014, 23: 22–33 (SCI, IF 6.696)

6. Xu YQ, Tao F, Ma CQ*, Xu P, New constitutive vectors: useful genetic engineering tools for biocatalysis. Appl. Environ. Microbiol. 2013, 79: 2836–2840. (SCI, IF 4.406)

7. Li LX, Zhang LJ, Li K, Wang Y, Gao C, Han BB, Ma CQ*, Xu P, A newly isolated Bacillus licheniformis strain thermophilically produces 2,3-butanediol, a platform and fuel bio-chemical. Biotechnol Biofuels. 2013, 6: 123 (SCI, IF 6.459)

8. Zheng ZJ, Sheng BB, Ma CQ*, Zhang HW, Gao C, Su F, Xu P, The relative catalytic efficiency of ldhL- and ldhD-encoded products is crucial for the optical purity of lactic acid produced by Lactobacillus strains, Appl. Environ. Microbiol. 2012, 78: 3480-3483 (SCI, IF 4.406)

9. Gao C, Hu CH, Zheng ZJ, Ma CQ*, Jiang TY, Dou PP, Zhang W, Che B, Wang YJ, Lv M, Xu P, Lactate utilization is regulated by the FadR-type regulator LldR in Pseudomonas aeruginosa, J. Bacteriol. 2012, 194: 2687-2692 (SCI, IF 3.593)

10. Liu Z, Ma CQ*, Gao C, Xu P, Efficient utilization of hemicellulose hydrolysate for propionic acid production using Propionibacterium acidipropionici. Bioresour. Technol. 2012, 114:711-714 (SCI, 5.172)

11. Li LX, Wang Y, Zhang LJ, Ma CQ*, Wang AL, Tao F, Xu P, Biocatalytic production of (2S,3S)-2,3-butanediol from diacetyl using whole cells of engineered Escherichia coli. Bioresour. Technol. 2012, 115:111-116 (SCI, IF 5.172)

12. Liu Z, Qin JY, Gao C, Hua DL, Ma CQ*, Li LX, Wang Y, Xu P, Production of (2S,3S)-2,3-butanediol and (3S)-acetoin from glucose using resting cells of Klebsiella pneumonia and Bacillus subtilis, Bioresour. Technol. 2011,102:10741-4 (SCI, IF 5.172)

13. Xu X, Gao C, Zhang X, Che B, Ma CQ*, Qiu J, Tao F, Xu P, Production of N-acetyl-D-neuraminic acid by use of an efficient spore surface display system. Appl Environ Microbiol, 2011, 77: 3197-201, (SCI, IF 4.406)

14. Xiao ZJ, Lv CJ, Gao C, Qin JY, Ma CQ*, Liu Z, Liu PH, Li LX, Xu P, A novel whole-cell biocatalyst with NAD+ regeneration for production of chiral chemicals, PLoS ONE, 2010, 5: e8860 (SCI, IF 4.244)


1. A process for producing chirally pure (2S,3S)-2,3-butanediol, Chinese invention patent, ZL 201110021066.5

2. A process for producing 2,3-butanediol and its special Bacillus licheniformis, Chinese invention patent, ZL 201110369152.5

3. One process for producing (2S,3S)-2,3-butanediol, and (3S)-acetoin from glucose, Chinese invention patent, ZL 201110247505.4

4. Directed evolution of L-lactate dehydrogenase and its application, Chinese invention patent, ZL 201210010514.6

5. A method for production of D-2-hydroxy-butanoic acid, Chinese invention patent, ZL 201010297333.7

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