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Liangcheng Du
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E-mail: ldu3@unl.edu
Title: Professor

EDUCATION

PhD 1993.9-1997.1 Royal Veterinary and Agricultural University Biochemistry

MS 1986.8-1989.7 Kunming Institute of Botany, CAS Biochemistry

BS 1982.9-1986.7 Yunnan University Biology

WORK EXPERIENCE

1997.1-2001.7 University of California, Davis Postdoc

2001.8-2007.7 University of Nebraska-Lincoln Assistant Professor

2007.8-2013.7 University of Nebraska-Lincoln Associate Professor (with tenure)

2013.8-Present University of Nebraska-Lincoln Professor

2011.9-Present Shandong University Taishan Scholar (Adjunct Professor)

RESEARCH INTEREST

1. Antibiotics and other bioactive natural products from underexplored biocontrol bacteria and endophytic fungi

2. Molecular mechanisms for natural product biosynthesis, metabolic engineering and synthetic biology

3. Food-borne mycotoxins and biosynthetic mechanisms

RESEARCH PROJECTS

1. NSFC Collaborative Research Fund for Overseas, Hong Kong & Macao Scholars (31028019, 2011.01-2012.12; renewed, 31329005, 2014.01-2017.12),“Isolation and Biosynthetic Studies of New Natural Products against Rice Pathogens from Lysobacter enzymogene” (PI)

2. National Basic Research Program (973) of China (2013CB734002, 2013.01-2017.12), “Discovering New Heterologous Modules and Chassis for Synthetic Biology Application” (Participant)

3. NSFC Key Project (81530091, 2016.01-2020.12), “Novel Skeleton Panning, Functional-orientated Biosynthesis and Targeted-production of Ansamycins” (Participant)

SELECTED PUBLICAITONS

1. Zhao Y, Qian G, Ye Y, Wright S, Chen H, Shen Y, Liu F*, andDu L*. 2016. Heterocyclic aromatic N-oxidation in the biosynthesis of phenazine antibiotics from Lysobacter antibioticus. Organic Letters 18: 2495-2498.

2. Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, Qian G, Liu F, Shen Y*, andDu L*. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Applied Microbiology and Biotechnology 99: 801-811.

3. Li Y, Chen H, Ding Y, Xie Y, Wang H, Cerny RL, Shen Y*, andDu L*. 2014. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angewandte Chemie International Edition 53: 7524-7530.

4. Wang Y, Qian G, Liu F, Li Y-Z, Shen Y, andDu L*. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synthetic Biology 2: 670-678.

5. Wang Y, Qian G, Li Y, Wang YS, Wang YL, Wright S, Li Y-Z, Shen Y, Liu F, andDu L*. 2013. Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes. PLOS One 8(6): e66633.

6. Xie Y, Wright S, Shen Y, andDu L*. 2012. Bioactive natural products from Lysobacter. Natural Product Reports 29: 1277-1287.

7. Lou L, Chen H, Cerny RL, Li Y, Shen Y, andDu L*. 2012. Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3. Biochemistry 51, 4-6.

8. Zhang W, Li Y, Qian G, Wang Y, Chen H, Li Y-Z, Liu F, Shen Y*, andDu L*. 2011. Identification and characterization of the anti-methicillin resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11.Antimicrobial Agents and Chemotherapy 55: 5581-5589.

9. Lou L, Qian G, Xie Y, Hang J, Chen H, Zaleta-Rivera K, Li Y, Shen Y, Dussault PH, Liu F*, andDu L*. 2011. Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. Journal of American Chemical Society 133: 643-645.

10.Du L*and Lou L. 2010. PKSs and NRPSs release mechanisms. Natural Product Reports 27: 255-278.

11. Gerber R, Lou L, andDu L*. 2009. A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides. Journal of American Chemical Society 131: 3148-3149.

12. Zhu X, Vogeler C, andDu L*. 2008. Functional complementation of fumonisin biosynthesis in FUM1-disrupted Fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici. Journal of Natural Products 71:957-960.

13. Zhu X, Yu F, Li X-C, andDu L*. 2007. Production of dihydroisocoumarins in Fusarium verticillioides by swapping the ketosynthase domain of the fungal iterative modular polyketide synthase Fum1p with that of lovastatin diketide synthase. Journal of American Chemical Society 129: 36-37.

14. Yu F, Zaleta-Rivera K, Zhu X, Huffman J, Millet J, Harris SD, Yuen G, Li X, andDu L*. 2007. Structure and biosynthesis of HSAF, a broad spectrum antimycotic with a novel mode of action. Antimicrobial Agents and Chemotherapy 51: 64-72.

15. Zaleta-Rivera K, Xu C, Yu F, Butchko RAE, Proctor RH, Lara MEH, Raza A, Dussault PH, andDu L*. 2006. A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins. Biochemistry 45: 2561-2569.


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