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Min XIAO
Phone number: 0531-88365128
Fax number: 
E-mail: minxiao@sdu.edu.cn
Title: Professor

EDUCATION & EXPERIENCE

2001-present Professor, State Key Lab of Microbial Technology, Shandong University

1996-2000 Associate Professor, State Key Lab of Microbial Technology, Shandong University

1988-1995 Assistant and Lecturer, Department of Microbiology, Life Science School, Shandong University

2003 Visiting scholar, Deptment of Chemistry, Wayne State University, USA

1997-1998 UESCO International Postgraduate University Course in Microbiology in Japan, Kyoto University

1996-2000 Ph.D. in Microbiology, Shandong University

1985-1988 M.Sc. in Microbiology, Shandong University

1981-1985 B.Sc. in Microbiology, Shandong University

RESEARCH INTEREST

1. Enzyme-catalyzed glycosylation.

2. Nicotine metabolism in fungi.

3. Carotenoid biosynthesis in phototrophic bacteria

RESEARCH PROGRAMS

1. National Natural Science Foundation of China (NSFC) (31670062): Molecular evolution of α-L-rhamnosidase for enzymatic rhamnosylation of antitumor drugs.

2. National Key Basic Research Program of China (973 Program) (2012CB822102): Biosynthesis of glycan probes.

3. National Natural Science Foundation of China (NSFC) (31170054): Metabolism pathway, enzymes and genes responsible for nicotine catabolism by Aspergillus oryzae.

4. National Natural Science Foundation of China (NSFC) (31070064): Molecular evolution of levansucrase for broad substrate specificity in the transfructosylation.

5. National Natural Science Foundation of China (NSFC) (30970028): Carotenoids biosynthesis and the phytoene desaturase in Rhodobacter azotoformans.

6. National Natural Science Foundation of China (NSFC) (30770065): Molecular evolution of -Galactosidase capable of glycosyl transfer.

7. National High Technology Research and Development Programof China (863 Program) (2006AA10Z338): Molecular evolution of glycosidase for production of galacto-oligosaccharides.

8. National Natural Science Foundation of China (NSFC) (30170008): Regioselectivity in the transglycosylation of -D-galactosidase from Bifidobacterium.

SELECTED PUBLICATIONS (2014-2016)

1. Xiaodi Chen, Li Xu, Lan Jin, Bin Sun, Guofeng Gu, Lili Lu*,Min Xiao*.Efficient and regioselective synthesis of β-GalNAc/GlcNAc-lactose by a bifunctional transglycosylating β-N-acetylhexosaminidase from Bifidobacterium bifidum. Appl Environ Microbiol. 2016, 82(18):5642-5652.

2. Li Xu, Xiaohong Liu, Zhenhao Yin, Qian Liu, Lili Lu,Min Xiao*.Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design. Appl Microbiol Biotechnol. 2016, 100(24):10385-10394.

3. Wei Gong,Li Xu,Guofeng Gu,Lili Lu,Min Xiao*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis. Appl Microbiol Biotechnol 2016,100: 6693–6702.

4. Lijuan Xu, Tingting Qi, Li Xu, Lili Lu* &Min Xiao*. Recent progress in the enzymatic glycosylation of phenolic compounds. Journal of Carbohydrate Chemistry. 2016, 35(1):1-23.

5. Jie Zhang, Lili Lu, Li Lu, Yang Zhao, Liping Kang, Xu Pang, Jingyuan Liu, Tengchuan Jiang,Min Xiao*, Baiping Ma*. Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricus L3. Glycoconj J. Glycoconj J. 2016, 33(1):53-62.

6. Shuquan Fan, Huaqin Zhang, Xiaodi Chen, Lili Lu, Li Xu andMin Xiao*. Cloning, characterization, and production of three -L-fucosidases from Clostridium perfringens ATCC 13124. J Basic Microbiol. 2015, 55(4), 347-357.

7. Lili Lu, Qian Liu, Lan Jan, Zhenghao Yin, Li Xu,Min Xiao*. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis. PLoS One. 2015, 10(10):e0140531.

8. Lili Lu, Yuchuan Guo, Lijuan Xu, Tingting Qi, Lan Jin, Li Xu,Min Xiao*. Galactosylation of caffeic acid by an engineered β-galactosidase. Drug Discoveries & Therapeutics. 2015; 9(2):123-128.

9. Lili Lu, Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu,Min Xiao*. Glycosylation of Phenolic Compounds by the Site-Mutated β-Galactosidase from Lactobacillus bulgaricus L3. PLoS ONE. 2015, 10(3): e0121445.

10. Lili Zhang, Lili Lu, Shuquan Fan, Lan Jin, Guofeng Gu, Li Xu andMin Xiao*. One-step synthesis of -Gal epitope and globotriose derivatives by an engineered -galactosidase. RSC Advances, 2015, 5, 22361 – 22364.

11. Li Xu, Dongxue Wang, Lili Lu, Lan Jin, Jiawei Liu, Deyong Song, Zhongwu Guo,Min Xiao*. Purification, Cloning, Characterization, and N-Glycosylation Analysis of a Novel -Fructosidase from Aspergillus oryzae FS4 Synthesizing Levan- and Neolevan-Type Fructooligosaccharides. PLoS ONE. 2014, 9(12): e114793.

12. Lili Lu, Feng Fu, Renfei Zhao, Lan Jin, Chunjuan He, Li Xu,Min Xiao*. A recombinant levansucrase from Bacillus licheniformis 8-37-0-1catalyzes versatile transfructosylation reactions. Process Biochem. 2014, 49: 1503-1510.

LICENSED PATENTS

ZL 2005 1 0044096.2 ZL 2010 1 0173646.1 ZL 2011 1 0119959.3

ZL 2005 1 0044097.7 ZL 2010 1 0220786.X ZL 2012 1 0156757.0

ZL 2005 1 0044897.9 ZL 2008 1 0139284.7 ZL 2013 1 0257432.6

ZL 2005 1 0044095.8 ZL 2010 1 0216912.4 ZL 2013 1 0121813.1

ZL 2005 1 0044898.3 ZL 2011 1 0190899.4 ZL 2013 1 0256580.6

ZL 2007 1 0015198.0 ZL 2011 1 0190960.5 ZL 2013 1 0257340.8

ZL 2008 1 0014906.3 ZL 2011 1 01909408.8 ZL 2013 1 0256401.9

ZL 2007 1 0116242.7 ZL 2011 1 0002979.2 ZL 2013 1 0257383.6

ZL 2008 1 0157830.X ZL 2010 1 0173582.5 ZL 2013 1 0255797.5


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