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Xu Fang
Phone number: 0531-88364004
Fax number: 
E-mail: fangxu@sdu.edu.cn
Title: Professor


Ph.D Bioengineering Kyoto University

Master Bioengineering Kyoto University

Bachelor B. E. Food Science and Engineering Tianjin University of Commerce


1、1995/7-1999/1 Department of Food and Biotechnology, Guangxi University Assistant Professor

2、2006/5-2009/4 National Institute of Advanced Industrial Science and Technology(AIST) Scientist

3、2009/5- Shandong University Professor


1. Cellulase synethesis machasism in filamentous fungi

2. Cellulolytic enzyme system

3. Modification of glycoside hydrolases

4. Mechanism of biomass degradation


1. National High-Tech R&D Program of China (863 program, No. 2014AA021903)

2. National Key Technology R&D Program of China (No. 2014BAD02B07),

3. Shandong Scientific and Technology Project (No. 2014CGZH1312)

4. National Energy Applied Technology Research and Demonstration Project (No. NY20130402)

5. Shandong Province Natural Science Foundation (No. ZR2013CM041)

6. National High-tech R&D program of China (863 program, No. 2011AA022302)

7. National Natural Science Foundation of China (No. 31200051)

8. Shandong Province Natural Science Foundation (No.ZR2012CQ022)

9. Scientific Research Foundation for the Returned Overseas Chinese Scholars

10. State Education Ministry


Book chapter:

1. Mingyu Wang, Zhonghai Li, Xu Fang, Lushan Wang and Yinbo Qu. Cellulolytic Enzyme Production and Enzymatic Hydrolysis for Second-Generation Bioethanol Production. 《Biotechnology in china III: Biofuels and Bioenergy》. p1-24, Springer, 2012

Research & review Paper:


1. Song H, Xu J, Lv N, et al. Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway[J]. Biochemical and Biophysical Research Communications, 2016, doi: 10.1016/j.bbrc.2016.07.052.

2. Wang M, Zhao Q, Li L, et al. Contributing factors in the improvement of cellulosic H2 production in Clostridium thermocellum/Thermoanaerobacterium co-cultures[J]. Applied Microbiology and Biotechnology, 2016, 100(19): 8607-8620.

3. Liu K, Dong Y, Wang F, et al. Regulation of cellulase expression, sporulation, and morphogenesis by velvet family proteins in Trichoderma reesei[J]. Applied Microbiology and Biotechnology, 2016, 100(2): 769-779.

4. Wang F, Jiang Y, Guo W, et al. An environmentally friendly and productive process for bioethanol production from potato waste[J]. Biotechnology for Biofuels, 2016, 9(1):50.

5. Jiang B, Zhang R, Feng D, et al. A tet-on and cre-loxP based genetic engineering system for convenient recycling of selection markers in Penicillium oxalicum[J]. Frontiers in Microbiology, 2016, 7:485.


6. Li Z, Yao G, Wu R, et al. Synergistic and dose-controlled regulation of cellulase gene expression in Penicillium oxalicum[J]. PLoS Genetics, 2015, 11(9): e1005509.

7. Sun F F, Hong J, Hu J, et al. Accessory enzymes influence cellulase hydrolysis of the model substrate and the realistic lignocellulosic biomass[J]. Enzyme and Microbial Technology, 2015, 79: 42-48.

8. Wang M, Yang H, Zhang M, et al. Functional analysis of Trichoderma reesei CKIIα2, a catalytic subunit of casein kinase II[J]. Applied Microbiology and Biotechnology, 2015, 99(14): 5929-5938.

9. Wang F, Liu K, Han L, et al. Function of a p24 Heterodimer in morphogenesis and protein transport in Penicillium oxalicum[J]. Scientific Reports, 2015, 5:11875.

10. Wang M, Han L, Liu S, et al. A Weibull statistics‐based lignocellulose saccharification model and a built‐in parameter accurately predict lignocellulose hydrolysis performance[J]. Biotechnology Journal, 2015, 10(9): 1424-1433.


11. Wang M, Dong Y, Zhao Q, et al. Identification of the role of a MAP kinase Tmk2 in Hypocrea jecorina (Trichoderma reesei)[J]. Scientific reports, 2014, 4:6732.

12. Zhang S, Liu C, Jin Y, et al. Studies on the isolation and culture of protoplasts from Kappaphycus alvarezii[J]. Acta Oceanologica Sinica, 2014, 33(10): 114-123.


13. Wang F, Liang Y, Wang M, et al. Functional diversity of the p24γ homologue Erp reveals physiological differences between two filamentous fungi[J]. Fungal Genetics and Biology, 2013, 61: 15-22.

14. Tang H, Hou J, Shen Y, et al. High β-glucosidase secretion in Saccharomyces cerevisiae improves the efficiency of cellulase hydrolysis and ethanol production in simultaneous saccharification and fermentation[J]. Journal of Microbiology Biotechnology, 2013, 23(11): 1577-1585.

15. Wang M, He D, Liang Y, et al. Factors involved in the response to change of agitation rate during cellulase production from Penicillium decumbens JUA10-1[J]. Journal of Industrial Microbiology & Biotechnology, 2013, 40(9): 1077-1082.

16. Wang M, Mu Z, Wang J, et al. The identification of and relief from Fe 3+ inhibition for both cellulose and cellulase in cellulose saccharification catalyzed by cellulases from Penicillium decumbens[J]. Bioresource Technology, 2013, 133: 507-512.

17. Wang M, Zhao Q, Yang J, et al. A mitogen-activated protein kinase Tmk3 participates in high osmolarity resistance, cell wall integrity maintenance and cellulase production regulation in Trichoderma reesei[J]. PloS One, 2013, 8(8): e72189.

18. Liu G, Zhang L, Qin Y, et al. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes[J]. Scientific Reports, 2013, 3.

19. Wang M, Liu K, Dai L, et al. The structural and biochemical basis for cellulose biodegradation[J]. Journal of Chemical Technology and Biotechnology, 2013, 88(4): 491-500.

20. Zhang J, Wang M, Gao M, et al. Efficient acetone–butanol–ethanol production from corncob with a new pretreatment technology—wet disk milling[J]. BioEnergy Research, 2013, 6(1): 35-43.


21. Wang M, Li Z, Fang X, et al. Cellulolytic enzyme production and enzymatic hydrolysis for second-generation bioethanol production[J] . Advances in Biochemical Engineering / Biotechnology, 2012, 128:1-24.


22. Zhang J, Fang X, Zhu X L, et al. Microbial lipid production by the oleaginous yeast Cryptococcus curvatus O3 grown in fed-batch culture[J]. Biomass and Bioenergy, 2011, 35(5): 1906-1911.

23. Hideno A, Inoue H, Tsukahara K, et al. Production and characterization of cellulases and hemicellulases by Acremonium cellulolyticus using rice straw subjected to various pretreatments as the carbon source[J]. Enzyme and Microbial Technology, 2011, 48(2): 162-168.


24. Fang X, Shen Y, Zhao J, et al. Status and prospect of lignocellulosic bioethanol production in China[J]. Bioresource Technology, 2010, 101(13): 4814-4819.

25. Liu K, Lin X, Yue J, et al. High concentration ethanol production from corncob residues by fed-batch strategy[J]. Bioresource Technology, 2010, 101(13): 4952-4958.


1. ZL 201210579233.2

2. ZL201210445856.0

3. ZL 201210571262.4

4. ZL 201310125106.x

5. ZL 201310293378.0

6. ZL 201310384284.4

7. ZL201110304843.7

8. ZL 201310142896.2

9. ZL201110298186.X

10. ZL 201310125472.5

11. US8034596, 2011-10-11,EP2150615, 2012-01-11,JP4986038, 2012-05-11,TWI410490,IDP000034914,Feb. 2015,WO2008/ 139641

12. JP4998991

13. ZL 201310384161.0

14. ZL 201310383366.7


1、2011 State Technological Innovation Award

2、2015 Technological Progress Award of National Light Industry Federation

3、2011 Shandong May 4th Youth Medal

4、2014 Shandong Province Award for Entrepreneurship of Oversea Returnes

5、2014 Award for Excellent papers of Chinese Journal of Biotechnology

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