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Yinbo Qu
Phone number: 0531-88365954
Fax number: 
E-mail: quyinbo@sdu.edu.cn
Title: Professor

EDUCATION

Ph.D 1982-1986, Institute of Microbiology, Shandong University

1981-1982, International Post-Graduate University Course in Microbiology, Osaka University and The University of Tokyo;

Master 1978-1981, Institute of Microbiology, Shandong University

Bachelor 1972-1974, Department of Biology, Shandong University

WORK EXPERIENCE

1978-now, research assistant, lecturer, associate professor, professor in Shandong University, including:

1993-1994, visiting scholar, Lund University, Sweden;

1998-1999, visiting scholar, Kyoto University, Japan.

1974-1978, Technician, Jining Distillery, Shandong.

1970-1972, worker, Jining Distillery, Shandong.

RESEARCH INTERESTS

1. Biodegradation of lignocellulosics by microorganisms;

2. Lignocellulosic enzyme system of Penicillium sp.; enzyme engineering and cellulases production;

3. Microbial technology for bioconversion of renewable biomass resource, especially biorefinery of lignocellulosics for cellulosic ethanol production.

RESEARCH PROGRAMS

1. National Key Basic Research Development Program (973 Program) Project 2011CB707400: Research on the key scientific issues in the efficient biodegradation and transformation of lignocellulosic resources

2. Key Project of National Natural Science Foundation of China (31030001): Omics analysis of the regulation network and mechanism for the cellulase system synthesis by Penicillium decumbens

3. Key Special Project for Science and Technology Development of Shandong Province, The technology for enzymatic hydrolysis of straw pulping waste residue and fermentation production of fuel ethanol

SELECTED PUBLICATIONS

1.Synergistic and Dose-controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum. Plos Genet, 2015. DOI: 10.1371/journal.pgen.1005509.

2.Redesigning the regulatory pathway to enhance cellulase production in Penicillium oxalicum. Biotechnol Biofuels 2015, 8:71 doi:10.1186/s13068-015-0253-8.

3.Functional characterization of protein kinase CK2 regulatory subunit regulating Penicillium oxalicum asexual development and hydrolytic enzyme production, Fungal Genet Biol, 2014, 66: 44-53.

4.Development of highly efficient, low-cost lignocellulolytic enzyme systems in the post-genomic era, Biotechnol Adv, 2013, 31 (6): 962-975.

5.Promotion of extracellular lignocellulolytic enzymes production by restraining the intracellular β-glucosidase in Penicillium decumbens, Bioresource Technol, 2013, 137: 33-40.

6.Cellodextrin transporters play important roles in cellulase induction in the cellulolytic fungus Penicillium oxalicum. Appl Microbiol Biotechnol. 2013, 97(24):10479-88.

7.Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. 2013, Scientific Reports, 3: 1569 | DOI: 10.1038/srep01569,

8.Genomic and Secretomic Analyses Reveal Unique Features of the Lignocellulolytic Enzyme System of Penicillium decumbens. 2013, PLoS ONE 8(2): e55185.

9.Transcription analysis of lignocellulolytic enzymes of Penicillium decumbens 114-2 and its catabolite-repression-resistant mutant, Comptes Rendus Biologies, 2011, 334: 806-811.

10.Purification and characterization of a novel cellobiohydrolase (PdCel6A) from Penicillium decumbens JU-A10 for bioethanol production, Bioresource Technology, 2011, 102: 8339-8342.

11.N-Glycoform Diversity of Cellobiohydrolase I from Penicillium decumbens and Synergism of Nonhydrolytic Glycoform in Cellulose Degradation, 2012, J Biol Chem, 287(19);15906–15915.

12.Ras GTPases Modulate Morphogenesis, Sporulation and Cellulase Gene Expression in the Cellulolytic Fungus Trichoderma reesei, 2012, PLoS ONE, 7(11)e48786.

13.Improved biomass saccharification by Trichoderma reesei through heterologous expression of lacA gene from Trametes sp. AH28-2, 2012, J Biosci Bioeng, 113 (6): 697–703.

14.Improved cellulase production via disruption of PDE01641 in cellulolytic fungus Penicillium decumbens, Bioresource Technology 123 (2012) 733–737.

15.High concentration ethanol production from corncob residues by fed-batch strategy. Bioresource Technology, 2010, 101: 4952-4958.

16.Status and prospect of lignocellulosic bioethanol production in China. Bioresource Technology, 2010, 101: 4814-4819.

17.Isolation and characterization of a β-glucosidase from Penicillium decumbens and improving hydrolysis of corncob residue by using it as cellulase supplementation, 2010, Enzyme Microb. Technol., 46: 444-449.

18.Characterization of the endoglucanase and glucomannanase activities of a glycoside hydrolase family 45 protein from Penicillium decumbens 114-2, , J Gen Appl Microbiol, 2010, 56 (3): 223-229.

19.Molecular cloning and characterization of two major endoglucanases from Penicillium decumbens, 2010, J. Microbiol. Biotechnol., 20(2): 265-270.

20.Genome shuffling improves production of cellulase by Penicillium decumbens JU-A10,2009,J. Appl. Microbiol., 107,1837-1846.

21.Engineering endoglucanase II from Trichoderma reesei to improve the catalytic efficiency at a higher pH optimum, J Biotechnol, 2008, 135/2: 190-195

22.The composition of basal and induced cellulase systems in Penicillium decumbens under induction or repression conditions, Enzyme Microb Technol, 2008, 42: 560-567.

23.Effect of oxygen limitation on xylose fermentation, intracellular metabolites and key enzymes of Neurospora crassa. Appl. Biochem. Biotechnol. 2008, 145-148.

24.Hydrogen production from cellulose by co-culture of Clostridium thermocellum JN4 and Thermoanaerobacterium thermosaccharolyticum GD17, Int J Hydrogen Energ, 2008, 33: 2927-2933.

25.Studies on Cellulosic Ethanol production for Sustainable Supply of Liquid Fuel in China,Biotechnol. J. 2006, 1(11): 1235-1240.

26.Directed evolution for engineering pH profile of endoglucanases III from Trichoderma reesei, Biomol. Eng., 2005, 22: 89-94.

27.Cold adaptation of a mesophilic cellulase, EG III from Trichoderma reesei, by directed evolution, 2002, Science in China (Series C), 45 (4): 337-343.

28.Studies on the key amino acid residues responsible for the alkali-tolerance of the xylanase by site-directed or random mutagenesis, 2002, J. Mol. Catal. B: Enzym. 18: 307-313.

29.Cellulose-binding domain of endoglucanase III from Trichoderma reesei disrupting the structure of cellulose, 2001, Biotechnol Lett, 23: 711-715.

30.Asparagine residue at position 71 is responsible for alkali-tolerance of the xylanase from Bacillus pumilus A-30, 2001, J Microbiol Biotechnol,11 (3): 534-538.

31.Enzymatic modification of straw pulp and characterization of alkaline xylanases from Pseudomonas sp. 1998, Enzyme Engineering XIV, Ann NY Acad Sci, vol. 864, 474-478.

32.Primary studies on several cellulase components with special characteristics purified from Trichoderma pseudokoningii S38. 1997. Biotechnol. Appl. Biochem. 25, 181-187.

33.Wide distribution of cellobiose-oxidizing enzymes in wood-rot fungus indicates a physiological importance in lignocellulosics degradation. 1997. Biotechnol. Tech. 11,194-197.

34.Screening microbial strain for improving the nutritional value of wheat and corn straws as animal feed, 1997, Enzyme Microb. Technol., 20, 581-584,

35.Improvement of Wheat Straw Pulp Properties with an Alkali-tolerant Xylanase from Pseudomonas sp. G6-2. 1996, ACS Symp. Ser. No.655, 308-316.

36.Transglycosylation of extracellular -glucosidase of Trichoderma peudokoningii S38 and its function in regulation of cellulase biosynthesis.1996. J. Gen. Appl. Microbiol. 42,363-369.

37.Production, Characterization and Application of the Cellulase-free Xylanase from Aspergillus niger, 1996, Appl. Biochem. Biotechnol., 57/58, 375-381.

38.Regulation of cellulase synthesis in mycelial fungi: participation of ATP and cyclic AMP. 1995, Biotechnol. Lett. 17(6), 593-598.

39.Acceleration of ethanol production from paper mill waste fiber by supplementation with β-glucosidase. 1993. Enzyme Microb. Technol. 15(1), 62,

40.SCP production from steam exploded hemicellulose autohydrolysate by Trichosporon cutaneum, 1992, J. Ferment. Bioeng., 73(5), 386.

41.Cellulase production from spent sulfite liquor and paper-mill waste fiber. 1991, Appl. Biochem. Biotechnol. 28/29, 363.

42.Studies on fermentation products and metabolism of long chain alkyl diamine in microorganisms. 1986. Agric. Biol. Chem. 50(6), 1437.

PATENTS

1.Method for producing high activity cellulase, ZL 96116049.7

2.The process for improving the performance of straw pulp by xylanase, ZL 95112261.4

3.The method of fermentation production of cellulosic ethanol from corn cob processing residue, ZL 20061 0131965.X

4.A Penicillium oxalicum strain with increased cellulase and xylanase activity, ZL 201410160118

AWARDS

1.The technology and application for cellulosic ethanol production from corn cob residue, 2011 National Technology Invention Prize (second class)

2.The method of fermentation production of cellulosic ethanol from corn cob processing residue, 2013 China Patent Award by State Intellectual Property Office

3.Wheat straw pulp biobleaching and enzymatic modification technology, 2005 National Science and Technology Progress Award (second class)

4.Production of cellulase by the submerged fermentation of Penicillium derepressed mutants with waste fiber, 1998 National Technology Invention Award (fourth class)


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