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Aiying Li
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EDUCATION

Ph.D: 1997-2000, Central China Agricultural University, Biochemistry and Molecular Biology

Master: 1994-1990, Shandong University, Microbiology

Bachelor: 1990-1994, Shandong University, Microbiological Engineering

WORK EXPERIENCE

2001/3-2003/8, Max-Planck Institute for Chemical Ecology, Germany, Postdoctoral Researcher

2003/10-2005/10, The University of Tokyo, Japan, Postdoctoral Researcher

2005/12-2014/3, Central China Normal University, China, Associate Professor

2014-Present, Shandong University, China, Associate Professor

RESEARCH INTERESTS

1.Biosynthesis of microbial secondary metabolites: functional study on genes involved in the biosynthetic pathways of antibiotics

2.Utilization of extremophile resources: cloning and functional study on alkalophilic enzymes from alkalophilic microbes

RESEARCH PROGRAMS (Since 2010)

1. National Natural Science Foundation of China (2012.1-2015.12, No. 31170050)

2. National Natural Science Foundation of China (2008.1-2010.12, No. 30770036 )

3. Key Research and Development Program of Shandong Province (2016.1-2017.12, No. 2015GSF12101)

4. Specialized Research Fund for the Doctoral Program of Higher Education (2008.1-2010.12, No. 20070511004)

5. Fundamental Research Funds for the Central Universities (2013.1-2014.12, No. CCNU13F012)

SELECTED PUBLICATIONS(Since 2010)

1. Wang H, Li Z, Jia R, Hou Y, Yin J, Bian X, Li A, Müller R, Stewart A F, Fu J*, Zhang Y*. RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression. Nature Protocols, 2016/6,11:1175-79.

2. Lü J, He Q, Huang L, Cai X, Guo W, He J, Zhang L, Li A*. Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. PLoS One, 2015, 10(2):e0117690 (SCI, 5-year IF: 4.01).

3. Liu Y, Liu S, Yang T, Guo X, Jiang Y, Zahid KR, Liu K, Liu J, Yang J, Zhao H, Yang Y, Li A*, Qi C*.Expression, crystallization and preliminary X-ray diffraction analyses of Med-ORF10 in the biosynthetic pathway of an antitumor antibiotic medermycin. The Protein Journal. 2015 Dec;34(6):404-10

4. He Q, Li L, Yang T, Li R, Li A.*(2015). Functional characterization of a ketoreductase-encoding gene med-ORF12 involved in the formation of a stereospecific pyran ring during the biosynthesis of an antitumor antibiotic medermycin. PLoS ONE. 10(7): e0132431

5. Deng H, Cai X, Peng J, Hong H, Ichinose K, Li A*. Practical procedures for genetic manipulation systems for medermycin-producing Streptomyces sp. AM-7161. Journal of Basic Microbiology, 2010, 50(3): 299-301 (SCI, 5-year IF: 1.64)

6. Lü J, Wu X, Jiang Y, Cai X, Huang L, Yang Y, Wang H, Zeng A and Li A*. An extremophile Microbacterium strain and its protease production under alkaline conditions. Journal of Basic Microbiology, 2014, 54(5):378-385 (SCI, 5-year IF: 1.64)

PATENTS

1.Construction and application of a medermycin-high-yielding producer by genetic engineering, Li Aiying, Wan Juan, Wang Huili, April, 2014, ZL201210120018.6,

2.Construction and application of multipegene expression system composed of angolosamine biosynthesis and transfer genes. Li Aiying, Wang Huili, Cai Xiaofeng, May, 2011, ZL200910063347.X



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