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Master Tutor
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Master Tutor > Content  
Bin-Bin Xie
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Ph.D: 2004-2009, Microbiology, Shandong University

Bachelor: 2000- 2004, Biotechnology, Shandong University


2009 - Present, School of Life Sciences, State Key Laboratory of Microbial Technology, Shandong University


1. Diversity, environmental adaptation, and evolution of marine microorganisms

2. Structure-function relationship of enzymes

3. Nutrition strategies of microorganisms


1. 2014-2017, Assess the role of piezophilic bacteria in carbon cycle of the South China Sea, National Natural Science Foundation of China (PI: Jisong Fang, Tongji University)

2. 2015-2016, Diversity, Classification and Genetic and Physiological Basis for Ecological Adaptation of Arctic Sea Ice Pseudoalteromonas, National Natural Science Foundation of China

3. 2011-2014, A pilot-scale study of a novel elastase, National High-tech R&D Program of China (863 Program)

4. 2011-2013, Elastolytic mechanism of a novel elastase Pseudoalterin from deep-sea, National Natural Science Foundation of China


1. Chen XL, Dong S (Co-first author), Xu F, Dong F, Li PY, Zhang XY, Zhou BC, Zhang YZ, Xie BB*. 2016. Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase from Pseudoalteromonas sp. SM0524. Front Microbiol. 7:1120.

2. Rong JC, Liu M, Li Y, Sun TY, Pang XH, Qin QL, Chen XL, Xie BB*. 2016. Complete genome sequence of a marine bacterium with two chromosomes, Pseudoalteromonas translucida KMM 520(T). Mar Genomics. 26:17-20.

3. Xie BB, Li D, Shi WL, Qin QL, Wang XW, Rong JC, Sun CY, Huang F, Zhang XY, Dong XW, Chen XL, Zhou BC, Zhang YZ*, Song XY*. 2015. Deep RNA sequencing reveals a high frequency of alternative splicing events in the fungus Trichoderma longibrachiatum. BMC Genomics. 16:54.

4. Li H, Zhang XY (Co-first author), Liu C, Liu A, Qin QL, Su HN, Shi M, Zhou BC, Chen XL, Zhang YZ, Xie BB*. 2015. Bizionia arctica sp. nov., isolated from Arctic fjord seawater, and emended description of the genus Bizionia. Int J Syst Evol Microbiol. 65:2925-30.

5. Lin CY, Zhang XY (Co-first author), Liu A, Liu C, Song XY, Su HN, Qin QL, Xie BB*, Zhang YZ. 2015. Marivirga atlantica sp. nov., isolated from seawater and emended description of the genus Marivirga. Int J Syst Evol Microbiol. 65:1515-9.

6. Xie, B. B., Q. L. Qin, M. Shi, L. L. Chen, Y. L. Shu, Y. Luo, X. W. Wang, J. C. Rong, Z. T. Gong, D. Li, C. Y. Sun, G. M. Liu, X. W. Dong, X. H. Pang, F. Huang, W. Liu, X. L. Chen, B. C. Zhou, Y. Z. Zhang*, and X. Y. Song*. 2014. Comparative genomics provide insights into evolution of Trichoderma nutrition style. Genome Biol Evol 6:379-90.

7. Sun, M. L., S. B. Liu, L. P. Qiao, X. L. Chen, X. Pang, M. Shi, X. Y. Zhang, Q. L. Qin, B. C. Zhou, Y. Z. Zhang, and B. B. Xie*. 2014. A novel exopolysaccharide from deep-sea bacterium Zunongwangia profunda SM-A87: low-cost fermentation, moisture retention, and antioxidant activities. Appl Microbiol Biotechnol. 98:7437-45.

8. Su, H. N., L. Y. Ran, Z. H. Chen, Q. L. Qin, M. Shi, X. Y. Song, X. L. Chen, Y. Z. Zhang, and B. B. Xie*. 2014. The ultrastructure of type I collagen at nanoscale: large or small D-spacing distribution? Nanoscale 6:8134-9.

9. Zhao, H. L., J. Yang, X. L. Chen, H. N. Su, X. Y. Zhang, F. Huang, B. C. Zhou, and B. B. Xie*. 2014. Optimization of fermentation conditions for the production of the M23 protease Pseudoalterin by deep-sea Pseudoalteromonas sp. CF6-2 with artery powder as an inducer. Molecules 19:4779-90.

10. Qin QL, Xie BB*, Yu Y, Shu YL, Rong JC, Zhang YJ, Zhao DL, Chen XL, Zhang XY, Chen B, Zhou BC, Zhang YZ*. 2014. Comparative genomics of the marine bacterial genus Glaciecola reveals the high degree of genomic diversity and genomic characteristic for cold adaptation. Environ Microbiol 16:1642-53.

11. Li PY, Xie BB*, Zhang XY, Qin QL, Dang HY, Wang XM, Chen XL, Yu J, Zhang YZ*. 2012. Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea. Environ Microbiol 14:467-79.

12. Xie, B. B., Y. L. Shu, Q. L. Qin, J. C. Rong, X. Y. Zhang, X. L. Chen, M. Shi, H. L. He, B. C. Zhou, and Y. Z. Zhang*. 2012. Genome sequences of type strains of seven species of the marine bacterium Pseudoalteromonas. J Bacteriol 194:2746-7.

13. Xie, B. B., Y. L. Shu, Q. L. Qin, J. C. Rong, X. Y. Zhang, X. L. Chen, B. C. Zhou, and Y. Z. Zhang*. 2012. Genome sequence of the cycloprodigiosin-producing bacterial strain Pseudoalteromonas rubra ATCC 29570T. J Bacteriol 194:1637-8.

14. Bian, F., B. B. Xie(Co-first author), Q. L. Qin, Y. L. Shu, X. Y. Zhang, Y. Yu, B. Chen, X. L. Chen, B. C. Zhou, and Y. Z. Zhang*. 2012. Genome sequences of six Pseudoalteromonas strains isolated from Arctic sea ice. J Bacteriol 194:908-9.

15. Xie BB, Bian F(Co-first author), Chen XL, He HL, Guo J, Gao X, Zeng YX, Chen B, Zhou BC, Zhang YZ*. 2009. Cold adaptation of zinc metalloproteases in the thermolysin family from deep sea and arctic sea ice bacteria revealed by catalytic and structural properties and molecular dynamics: new insights into relationship between conformational flexibility and hydrogen bonding. J Biol Chem. 284:9257-69.

16. Xie BB, Chen XL, Zhang XY, He HL, Zhang YZ*, Zhou BC. 2008. Predicting protein interaction interfaces from protein sequences: case studies of subtilisin and phycocyanin. Proteins. 71:1461-74.


1. Young Scholars Program of Shandong University (2016-2021)

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