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Faculty and staff
Doctoral tutor
· botany
· Zoology
· microbiology
· ecology
Master Tutor
· botany
· Zoology
· microbiology
· ecology
Master Tutor > microbiology  
Haoxin Wang
Phone number: 86-531-88362350
Fax number: 
E-mail: wanghaoxin@sdu.edu.cn
Title: Lecturer

EDUCATION

Ph.D: Kunming Institute of Botany, Chinese Academy of Sciences (Botany, 2001/9 - 2008/1)

Bachelor: Anhui University (Biology, 1997/9 - 2001/7)

WORK EXPERIENCE

1、2010/6 – Now Shandong University Assistant Professor

2、2008/3 - 2010/3 Xiamen University Postdoc.

RESEARCH INTERESTS

1. Discovery of novel natural products from actinobacteria.

2. Biosynthetic mechanism of bioactive natural products.

3. Synthetic biology of natural products.

RESEARCH PROGRAMS

1. Rational discovery of new AHBA-containing natural products,National Natural Science Foundation of China (NSFC), 31570039, 2016/01-2019/12, ¥650,000

2. Discovery of novel ansamycins from cryptic gene cluster, National Natural Science Foundation of China (NSFC), 31100079, 2012/01-2014/12, ¥250,000

3. Discovery novel polyketides through heterologous expression of biosynthetic gene cluster, Independent Innovation Foundation of Shandong University (IIFSDU), 2010TS072, 2010/06-2012/12, ¥70,000

4. Function of ansamycin biosynthetic gene cluster isolated from metagenome of plant microbiota, China Postdoctoral Science Foundation funded project (CPSF), 20090450840, 2009/03-2010/03, ¥30,000

SELECTED PUBLICATIONS

1. G. Shi#; N. Shi#; Y. Li; W. Chen; J. Deng; C. Liu; J. Zhu; H. Wang*; Y. Shen*, d-Alanylation in the Assembly of Ansatrienin Side Chain is Catalyzed by a Modular NRPS. ACS chemical biology 2016, 11(4), 876-881.

2. S. Li#; Y. Li; C. Lu; J. Zhang; J. Zhu; H. Wang*; Y. Shen*, Activating a Cryptic Ansamycin Biosynthetic Gene Cluster To Produce Three New Naphthalenic Octaketide Ansamycins with n-Pentyl and n-Butyl Side Chains. Org Lett 2015, 17, 3706-9.

3. C. Liu#; J. Zhu; Y. Li; J. Zhang; C. Lu; H. Wang*; Y. Shen*, In Vitro Reconstitution of a PKS Pathway for the Biosynthesis of Galbonolides in Streptomyces sp. LZ35. Chembiochem 2015, 16, 998-1007.

4. C. Xie#; J. Deng; H. Wang*, Identification of AstG1, A LAL family regulator that positively controls ansatrienins production in Streptomyces sp. XZQH13. Curr Microbiol 2015, 70, 859-64.

5. J. Zhu#; W. Chen; Y. Li; J. Deng; D. Zhu; J. Duan; Y. Liu; G. Shi; C. Xie; H. Wang*; Y. Shen*, Identification and catalytic characterization of a nonribosomal peptide synthetase-like (NRPS-like) enzyme involved in the biosynthesis of echosides from Streptomyces sp. LZ35. Gene 2014, 546, 352-8.

6. S. Li#; H. Wang#; Y. Li; J. Deng; C. Lu; Y. Shen*, Biosynthesis of hygrocins, antitumor naphthoquinone ansamycins produced by Streptomyces sp. LZ35. Chembiochem 2014, 15, 94-102.

7. H. Wang#; Y. Chen; L. Ge; T. Fang; J. Meng; Z. Liu; X. Fang; S. Ni; C. Lin; Y. Wu; M. Wang; N. Shi; H. He; K. Hong; Y. Shen, PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J Appl Microbiol 2013, 115, 77-85.

8. C. Lu#; Y. Li#; J. Deng#; S. Li; H. Wang*; Y. Shen*, Hygrocins C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. J Nat Prod 2013, 76, 2175-2179.

9. Y. Jiang#; H. Wang#; C. Lu; Y. Ding; Y. Li; Y. Shen, Identification and characterization of the cuevaene A biosynthetic gene cluster in Streptomyces sp. LZ35. Chembiochem 2013, 14, 1468-1475.

10. H. Wang#; Z. Geng; Y. Zeng; Y. Shen, Enriching plant microbiota for a metagenomic library construction. Environ Microbiol 2008, 10, 2684-2691

PATENTS

1. Haoxin Wang,Ying Zeng,Yuemao Shen,The Protocol of plant microbiota preparation,2007.3.19-2027.3.19,China,ZL200710065724.4。


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