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Doctoral tutor
· botany
· Zoology
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Master Tutor
· botany
· Zoology
· microbiology
· ecology
Master Tutor > microbiology  
Jin Hou
Phone number: 0531-88365827
Fax number: 
E-mail: houjin@sdu.edu.cn
Title: Associate Professor

EDUCATION:

M.S. and Ph.D, 2004-2009, State Key Laboratory of Microbial Technology, Shandong University

Guest Ph.D, 2007-2008, Center for Microbial Biotechnology, Technical University of Denmark, Denmark

Bachelor, 2000-2004, Biotechnology, Shandong Agriculture University

WORK EXPERIENCE

1. 2012-present, Associate Professor, The State Key Laboratory of Microbial Technology, Shandong University

2. 2010-2012, Postdoc, Department of Chemical and Biological Engineering, Chalmers University of Technology, Sweden

3. 2009- 2010, Technical Coordinator, Green Biologics Ltd, UK

RESEARCH INTERESTS

1. The biofuels, chemicals and natural products biosynthesis in engineered microorganism such as Saccharomyces cerevisiae

2. The development of synthetic biology tools

3. The secretory pathway engineering for efficient protein production

RESEARCH PROGRAMS

1. 2015-2018, The module metabolic engineering of key precursor acetyl-CoA, its derived products synthesis and cofactor perturbation in Saccharomyces cerevisiae, National Natural Science Foundation of China (No. 31470163), 820 thousand yuan

2. 2014-2016, The study of protein secretion pathway engineering on the assembly of cellulosome in Saccharomyces cerevisiae, National Natural Science Foundation of China (No. 31300037), 230 thousand yuan

3. 2016-2017, The development of yeast platform for monoterpene geraniol production, the Key R & D Program of Shandong Province (No. 2015GSF121015), 100 thousand yuan

4. 2013-2015, The functional genomic analysis of high efficient cofactor independent xylose metabolic strains, Promotive research fund for excellent young, Middle-aged scientists of Shandong Province (No. BS2013SW020), 50 thousand yuan;

5. 2013-2015, Technology integration and industrialization of high clean gasoline and diesel production with straw and other low value biomass, National Key Technology R&D Program of China (2014BAD02B07), 480 thousand yuan

SELECTED PUBLICATIONS

2016

1. Jin Hou, Chunlei Jiao, Bo Peng, Yu Shen, Xiaoming Bao. Mutation of a regulator Ask10p improves xylose isomerase activity through up-regulation of molecular chaperones in Saccharomyces cerevisiae, Metab Eng. 2016, doi: 10.1016/j.ymben.2016.08.001.

2. Jianzhi Zhao, Xiaoming Bao, Chen Li, Yu Shen, Jin Hou*. Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae, Appl Microbiol Biotechnol. DOI 10.1007/s00253-016-7375-1

3. Hongting Tang, Wang Shenghuan, Wang Jiajing, Song Meihui, Xu Mengyang, Zhang Mingying, Yu Shen, Jin Hou*, Xiaoming Bao*, N-hypermannose glycosylation disruption enhances recombinant protein production by regulating secretory pathway and cell wall integrity in Saccharomyces cerevisiae. Sci Rep. 2016 May 9;6:25654. doi: 10.1038/srep25654.

2015

4. Hongting Tang, Xiaoming Bao, Yu Shen, Meihui Song, Shenhuan Wang, Chenqiang Wang, Jin Hou*. Engineering protein folding and translocation improves heterologous protein secretion in Saccharomyces cerevisiae, Biotechnol Bioeng. 2015, 112(9):1872-82

5. Jin Hou, Yu Shen, Chunlei Jiao, Xingjing Zhang, Xiaoming Bao, Characterization and evolution of xylose isomerase screened from the bovine rumen metagenome in Saccharomyces cerevisiae. J Biosci Bioeng. 2015, 2015 Jul 6. pii: S1389-1723(15)00207-8. doi: 10.1016/j.jbiosc.

2014

6. Jin Hou, Fan Suo, Chengqiang Wang, Xiaowei Li, Yu Shen, Xiaoming Bao. Fine-tuning of NADH oxidase decreases byproduct accumulation in respiration deficient xylose metabolic Saccharomyces cerevisiae. BMC Biotechnology 2014, 14:13

7. Jin Hou, Hongting Tang, Zihe Liu, Tobias Österlund, Jens Nielsen, Dina Petranovic. Management of the ER stress by activation of the heat shock response in yeast. FEMS Yeast Res, 2014, 14(3): 481–494

8. 酿酒酵母生物基化学品转化合成平台的研究进展,侯进,沈煜,鲍晓明,生物产业技术,2014,05(9):53-58

9. 酿酒酵母人造纤维小体的研究进展,汤红婷,侯进,沈煜,鲍晓明,生物加工过程,2014,12 (1):94-101

2013

10. Jin Hou, Tobias Österlund, Zihe Liu, Dina Petranovic, Jens Nielsen, Heat Shock Response Improves Heterologous Protein Secretion in Saccharomyces cerevisiae, Appl Microbiol Biotechnol, 2013; 97(8):3559-68

11. Hongting Tang1, Jin Hou1, Yu Shen, Lili Xu, Hui Yang, Xu Fang, Xiaoming Bao. High β-glucosidase secretion in Saccharomyces cerevisiae improves the efficiency of cellulase hydrolysis and ethanol production in simultaneous saccharification and fermentation. J Microbiol Biotechnol. 2013, 28;23(11):1577-85. 1contributed equally to the work

12. Zihe Liu, Jin Hou, José L. Martínez, Dina Petranovic, Jens Nielsen. Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae, Appl Microbiol Biotechnol. 2013; 97(20):8955-62.

2012

13. Jin Hou, Keith E.J. Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen, Engineering of Vesicle Trafficking Improves the Heterologous Protein Production in Saccharomyces cerevisiae, Metab Eng, 2012, 14(2):120-127

14. Jin Hou, Keith E.J. Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen, Metabolic Engineering of Recombinant Protein Secretion by Saccharomyces cerevisiae, FEMS Yeast Res, 2012, 12(5):491-510.

15. Kuk-Ki Hong1, Jin Hou1, Saeed Shoaie, Jens Nielsen, Sergio Bordel. Dynamic, (13) C-labeling experiments prove important differences in protein turnover rate between two Saccharomyces cerevisiae strains. FEMS Yeast Res, 2012, 12(7):741-747. 1contributed equally to the work

PATENTS

1. A high β-glucosidase secretion recombinant Saccharomyces cerevisiae strains and its application, ZL201310187648.X


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