徐志刚-山东大学生命科学学院
博士&硕士生导师
徐志刚
作者:   时间:2017-12-12   点击数:

徐志刚

 

办公电话:86-532-58630869

电子邮箱:xuzg@sdu.edu.cn

 

教育背景 

本科 1995.09 - 1998.07 烟台大学 生物化学

博士 1998.09 - 2004.01 复旦大学 遗传学 

工作经历

起止时间 单位名称 专业技术职务

2004.01–2004.12 中国国家人类基因组南方研究中心 科研人员

2005.01–2005.09 美国哈佛大学医学院 博士后

2005.10–2009.05 美国斯坦福大学医学院 博士后

2009.05–现在    山东大学生命科学学院 教授 

科研方向

1. 耳聋发生机制

2. 听纤毛发育及维持机制

3. 听觉转导分子机制 

代表性论文*通讯作者)

1.Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R*, Xu Z*. Loss of CIB2 causes profound hearing loss and abolishes mechanoelectrical transduction in mice. Front. Mol. Neurosci., 2017, 10: 401.

2.Cheng X, Shao M, Li J, Wang Y, Qi J, Xu Z*, Shi D*. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nat. Commun. 2017, 8: 1353.

3.Liu Y, Nie H, Liu C, Zhai X, Sang Q, Wang Y, Shi D, Wang L*, Xu Z*. Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1. Sci Rep. 2017 Aug 7;7(1):7466.

4.Liu C, Zhai X, Zhao B, Wang Y, Xu Z*. Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation. Sci Rep. 2017 Jan 23. 7:40979.

5.Liu C, Zhai X, Du H, Cao Y, Cao H, Wang Y, Yu X, Gao J, Xu Z*. Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice. Oncotarget. 2016 Sep 15. 7(42): 68921-32.

6.Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG*, Sun JP*. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein. J Biol Chem. 2014 Aug 29;289(35):24215-25.

7.Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S, Xu Z*. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. PLoS One. 2013; 8(2): e56516.

8.Xu Z, Ricci AJ, Heller S. Rethinking how hearing happens. Neuron. 2009; 62(3):305-7.

9.Xu Z, Peng AW, Oshima K, Heller S. MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23. J Neurosci. 2008; 28(44):11269-76.

10.Xu ZG, Du JJ, Zhang X, Cheng ZH, Ma ZZ, Xiao HS, Yu L, Wang ZQ, Li YY, Huo KK, Han ZG. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Hepatology. 2003;38(3):735-44. 

论著 

1. Xiong W, Xu Z. Mechanotransduction of the hair cell. Springer (April 28, 2018) 

 

 

 

 

 


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