博士&硕士生导师
张玉忠
作者:   时间:2017-12-12   点击数:

张玉忠

电 话:0531-88564326传 真:E-Mail:zhangyz@sdu.edu.cn

教育背景

博士 1992.7-1995.8 中国科学院海洋研究所

硕士 1989.9-1992.7 南京农业大学农学系

本科 1985.9-1989.7 山东师范大学生物系

工作经历

1995.9-1998.5 山东大学 博士后

1998.6-2000.8 山东大学 副教授

2000.9-至今 山东大学 教授

2001.9-至今 山东大学 博导

科研方向

1. Marine microbiology

l Physiology, biochemistry, diversity, ecology and biotechnology of marine bacteria in the oceanic extreme environments.

l Photosynthesis and evolution of cyanobacteria and red algae.

2. Marine biotechnology

l Application of novel enzymes and exopolysaccharides from marine bacteria.

3. Agricultural Microbiology

l Biology of filamentous fungiTrichodermaspp.

l Biocontrol of plant pathogens byTrichodermaspp. and interaction between plant andTrichodermaspp.

承担主要课题:

时 间

项 目 名 称

等级

位次

经费(万)

2017-2021

玫瑰杆菌(Roseobacter)参与海洋表层有机硫DMSP循环的机制及生理生态学适应的生物化学基础

国家自然基金重点项目

1

269

2013-2017

深海细菌适应深海极端环境的生理与遗传机制

国家基金重大项目

1

1500

2013-2017

深海细菌适应深海低温极端环境的生理与遗传机制

国家基金重大课题

1

700

2013-2016

南海深海有机质的生物降解过程及有机碳、有机氮代谢的偶联

国家自然基金重点项目

1

300

2011-2014

海洋适冷细菌的生理与生物化学研究

国家杰出青年自然基金

1

200

学术兼职

山东省人民政府聘为山东大学微生物学岗位“泰山学者”特聘教授,“十二五”国家863计划海洋技术领域海洋生物资源利用技术主题专家组专家,中国微生物学会海洋微生物学会副主任委员,国家自然科学基金委生命学部第13届学科评审专家组成员,中国大洋协会国际海底生物及基因资源中国工作组副组长, 国际微生物学主流杂志Applied and Environmental Microbiology的编委 (The Editorial board member),FEMS Micrbiology Letter的编辑(Editor)。

部分已经发表的论文(*表示通讯作者):

1. Zhang Y-Z, Li Y, Xie B-B, Chen X-L, Yao Q-Q, Zhang X-Y, Kempher ML, Zhou J, Oren A, Qin Q-L (2016) Nascent Genomic Evolution and Allopatric Speciation of Myroides profundi D25 in Its Transition from Land to Ocean. mBio, 7(1): e01946-15. doi:10.1128/mBio.01946-15.

2. Zi-Chao Yu, Xiu-Lan Chen, Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Qin, Bin-Bin Xie, Xi-Ying Zhang, Yong Yu, Bai-Cheng Zhou, Bo Chen and Yu-Zhong Zhang*,Filamentous phages prevalent in Pseudoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice, ISME Journal, 2015 Mar 17;9(4):871-81. 2014 Oct 10. doi: 10.1038/ismej.2014.185.

3. Peng Wang, Xiu-Lan Chen, Chun-Yang Li, Xiang Gao, Deyu Zhu, Bin-Bin Xie, Qi-Long Qin, Xi-Ying Zhang, Hai-Nan Su, Bai-Cheng Zhou, Luying Xun and Yu-Zhong Zhang*. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold. Molecular Microbiology. 2015, 98(2): 289-301.

4. Zi-Hao Mi, Zi-Chao Yu, Hai-Nan Su, Lei Wang, Xiu-Lan Chen, Xiuhua Pang, Qi-Long Qin, Bin-Bin Xie, Xi-Ying Zhang, Bai-Cheng Zhou and Yu-Zhong Zhang*, Physiological and genetic analyses reveal a mechanistic insight into the multifaceted lifestyles of Pseudoalteromonas sp. SM9913 adapted to the deep-sea sediment, Environmental Microbiology, 2015 Oct;17(10):3795-806.

5. Li CY, Wei TD, Zhang SH, Chen XL, Gao X, Wang P, Xie BB, Su HN, Qin QL, Zhang XY, Yu J, Zhang HH, Zhou BC, Yang GP, Zhang YZ*. Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide. Proc Natl Acad Sci U S A. 2014,111: 1026-1031.

6. Xiang Gao, Jue Wang, Da-Qi Yu, Fei Bian, Bin-Bin Xie, Xiu-Lan Chen Bai-Cheng Zhou, Lu-Hua Lai, Zhi-Xin Wang, Jia-Wei Wu*, Yu-Zhong Zhang*, Structural Basis for the Autoprocessing of Zinc Metalloproteases in the Thermolysin Family. Proc Natl Acad Sci U S A 2010, 107(41): 17569-74.

7. Qi-Long Qin, Yang Li, Yan-Jiao Zhang, Zhe-Min Zhou, Wei-Xin Zhang, Xiu-Lan Chen, Xi-Ying Zhang, Bai-Cheng Zhou, Lei Wang and Yu-Zhong Zhang*, Comparative genomics reveals a deep-sea sediment-adapted life style of Pseudoalteromonas sp. SM9913, The ISME Journal , 2011, 5(2): 274-84.

8. Ran LY, Su HN, Zhao GY, Gao X, Zhou MY, Wang P, Zhao HL, Xie BB, Zhang XY, Chen XL, Zhou BC, Zhang YZ*. Structural and Mechanistic Insights into Collagen Degradation by a Bacterial Collagenolytic Serine Protease in the Subtilisin Family. Molecular Microbiology, 2013, 90(5): 997-1010.

9. Xiang Gao, Tian-Di Wei, Nan Zhang, Bin-Bin Xie, Hai-Nan Su, Xi-Ying Zhang, Xiu-Lan Chen, Yu-Zhong Zhang*. Molecular insights into the terminal energy acceptor in cyanobacterial phycobilisome, Molecular Microbiology, 2012, 85(5): 907-915.

10. Xiang Gao, Nan Zhang, Tian-Di Wei, Hai-Nan Su, Bin-Bin Xie, Chuang-Chuang Dong, Xi-Ying Zhang, Xiu-Lan Chen, Bai-Cheng Zhou Zhi-Xin Wang, Jia-Wei Wu, Yu-Zhong Zhang*, Crystal Structure of the N-terminal Domain of Linker LR and the Assembly of Cyanobacterial Phycobilisome Rods. Molecular Microbiology, 2011, 82: 698-705.

11. Ping-Yi Li, Peng Ji, Chun-Yang Li, Yi Zhang, Guang-Long Wang, Xi-Ying Zhang,Bin-Bin Xie,Qi-Long Qin, Xiu-Lan Chen, Bai-Cheng Zhou, and Yu-Zhong Zhang*. Structural Basis for Dimerization and Catalysis of a Novel Esterase from the GTSAG Motif Subfamily of the Bacterial Hormone-sensitive Lipase Family. Journal of Biological Chemistry, 2014, 289: 19031-19041.

12. Ran LY, Su HN, Zhou MY, Wang L, Chen XL, Xie BB, Song XY, Shi M, Qin QL, Pang X, Zhou BC, Zhang YZ*, Zhang XY*. Characterization of a Novel Subtilisin-like Protease Myroicolsin from Deep sea bacterium Myroides profundi D25 and Molecular insight into its Collagenolytic Mechanism. Journal of Biological Chemistry, 2014, 289(9): 6041-6053.

13. Hui-Lin Zhao, Xiu-Lan Chen, Bin-Bin Xie, Ming-Yang Zhou, Xiang Gao, Xi-Ying Zhang, Bai-Cheng Zhou, Anthony S. Weiss and Yu-Zhong Zhang*, Elastolytic mechanism of a novel M23 metalloprotease pseudoalterin from deep-sea Pseudoalteromonas sp. CF6-2: cleaving not only glycyl bonds in the hydrophobic regions, but also peptide bonds in the hydrophilic regions involved in crosslinking, Journal of Biological Chemistry, 2012, 2012 Nov 16;287(47):39710-20

14. Yu-Kai Wang, Guo-Yan Zhao (co-first author), Yang Li, Xiu-Lan Chen, Bin-Bin Xie, Hai-Nan Su, Yao-Hui Lv, Hai-Lun He, Hong Liu, Jun Hu, Bai-Cheng Zhou, Yu-Zhong Zhang*, Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep-sea Pseudoalteromonas sp. SM9913: Binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix, Journal of Biological Chemistry, 2010, 285(19):14285-91

15. Bin-Bin Xie, Fei Bian, Xiu-Lan Chen, Hai-Lun He, Jun Guo, Xiang Gao, Yin-Xin Zeng, Bo Chen, Bai-Cheng Zhou, and Yu-Zhong Zhang*, Cold adaptation of zinc metalloproteases in the thermolysin family from deep-sea and Arctic sea-ice bacteria revealed by catalytic and structural properties and molecular dynamics: New insights into relationship between conformational flexibility and hydrogen-bonding, Journal of Biological Chemistry, 2009, 284: 9257-9269.

16. Guo-Yan Zhao, Xiu-Lan Chen (co-first author), Hui-Lin Zhao, Bin-Bin Xie, Bai-Cheng Zhou, Yu-Zhong Zhang*, Hydrolysis of insoluble collagen by deseasin MCP-01 from deep-sea Pseudoalteromonas sp. SM9913: Collagenolytic characters, collagen-binding ability of C-terminal PKD domain and Implication for its novel role in deep-sea sedimentary particulate organic nitrogen degradation, Journal of Biological Chemistry,2008, 283 (52): 36100-36107.

研究生招生与培养:

1、1999.9-至今 山东大学微生物技术国家重点实验室,硕士研究生导师,共招收硕士生30多名。

2、2001.9-至今 山东大学微生物技术国家重点实验室,博士研究生导师,共招收博士研究生20多名。

3、获山东大学硕士优秀论文1篇、优秀博士论文5篇,获山东省优秀博士论文2篇,获教育部百篇优秀博士论文提名奖1篇。

4、招生计划: 每年硕士生2名、博士生1-2名。

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