博士&硕士生导师
庞秀华
作者:   时间:2017-12-12   点击数:

庞秀华

电 话:86-531-88364590传 真:E-Mail:pangxiuhua@sdu.edu.cn

工作及学习经历:

2009.3- 至今 :教授,博士生导师,山东大学

2004.3-2009.12:讲师(Instructor),高级研究助理(Research associate senior),博士后,University of Texas Health Science Center at Tyler, USA.

2001.5-2004.2:博士后,University of Nancy I,France.

1996.9-2000.7:博士,华中农业大学

1989.9-1992.7:硕士,中国科学院武汉病毒研究所

1985.9-1989.7:学士,山东师范大学

研究领域:

1. 放线菌的基础生物学

2. 放线菌的基因组挖掘

3. 具有新型结构及生物活性的代谢产物的分离和鉴定

4. 病原细菌的毒力因子及致病机制

主持课题:

1,国家自然科学基金应急项目(31741001),2018-01至2018-12

2,国家自然科学基金面上项目(31470165),2015-01至2018-12

3,国家自然科学基金面上项目(81171540),2012-01至2015-12

4,国家自然科学基金面上项目(81071328),2011-01至2013-12

5,山东省自然科学基金面上项目(ZR2010HM007),2010-10至2013-10

6,山东大学自主创新基金(2012ZD031),2012-01至2014-12

部分发表论文:

*: 通讯作者;†:贡献等同

1. Zhang P, Wu L, Zhu Y, Liu M, Wang Y, Cao G, Chen XL, Tao M,Pang X*. 2017. Deletion of MtrA Inhibits Cellular Development of Streptomyces coelicolor and Alters Expression of Developmental Regulatory genes. Frontiers in Microbiology 8:2013.

2. Cao G, Zhang P, Gu Y,Pang X*. 2017. Gene Over expression in Streptomyces hygroscopicus Associated with DNA amplification. Current Microbiology 74:979-86.

3. Zhao Z, Shi T, Xu M, Brock NL, Zhao YL, Wang Y, Deng Z,Pang X*, Tao M*. 2016. Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes. Organic LETTERS 18(3):572-5.

4. Cao G, Howard ST, Zhang P, Wang X, Chen XL, Samten B, andPang X*. 2015. EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR. Microbiology 161:477-489.

5. Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, andPang X*. 2015. Production of the antibiotic FR-008/Candicidin in Streptomyces sp. FR-008 is coregulated by two regulators, FscRI and FscRIV, from different transcription factor families. Microbiology 161:539-552.

6. Zhang P, Wu H, Chen XL, Deng Z, Bai L, andPang X*. 2014. Regulation of the Biosynthesis of Thiopeptide Antibiotic Cyclothiazomycin by a Transcriptiona1 Regulator SHJG8833 in Streptomyces hygroscopicus 5008. Microbiology 160:1379-1392.

7. Cao G, Howard ST, Zhang P, Hou G, andPang X*. 2013. Functional analysis of the EspR binding sites upstream of espR in Mycobacterium tuberculosis. Current Microbiology 67:572-579.

8.Pang X*, Samten B, Cao G, Wang X, Tvinnereim A, Chen X, and Howard ST. 2013. MprAB regulates the espA operon in Mycobacterium tuberculosis, and modulates ESX-1 function and host cytokine response. Journal of Bacteriology 195:66-75.

9.Pang X, Howard ST. 2007. Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system of Mycobacterium tuberculosis. Journal of Bacteriology 189:6213-21.

10.Pang X, Vu P, Byrd TF, Ghanny S, Soteropoulos P, Mukamolova GV, 5.Wu S, Samten B, Howard ST. 2007. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology 153:1229-42.

11. Aigle B†,Pang X†, Decaris B, Leblond P. 2005. Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the dupliated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens. Journal of Bacteriology 187:2491-500.

12.Pang X, Aigle B, Girardet JM, Mangenot S, Pernodet JL, Decaris B, Leblond P. 2004. Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome. Antimicrobial Agents and Chemotherapy 48:575-88.

13.Pang X, Zhou X, Sun Y, Deng Z. 2002. Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions. Journal of Bacteriology 184:1958-65.

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