硕士生导师
沈煜
作者:   时间:2017-12-12   点击数:

姓名:沈煜

办公电话:0531-88365827

电子邮箱:shenyu@sdu.edu.cn

教育背景

起止时间 毕业院校 专业

博士 2000.9-2005.6 山东大学 微生物学

本科 1996.9-2000.6 山东大学 微生物学

工作经历

起止时间 单位名称  专业技术职务

2015/9-至今 山东大学生命科学学院 副教授

2009.6-2015.8   山东大学生命科学学院   讲师

2009.9 -2010.8 瑞典Chalmers技术大学生物化工系 博士后

2006.7 -2009.5 河南天冠企业集团 博士后

2005.7 -2006.6 江南大学生物工程学院  讲师 

科研方向

1. 酿酒酵代谢途径工程

2. 酿酒酵母糖代谢调控机制

3. 酿酒酵母对木质纤维素预处理原料毒性的耐受机制 

主持课题

1. 2018.1-2021.12,蛋白乙酰化修饰调节酿酒酵母碳源代谢机制的研究自然科学基金面上项目31770046

2. 2015.1-2018.12,酿酒酵母葡萄糖感应系统及代谢后继效应干扰木糖转化效率的机制研究,自然科学基金面上项目31470166

3. 2014.1-2016.12,纤维素酶和木糖醇高效生产菌株的构建,国家高技术研究发展计划(863计划)子课题 2014AA021903-03

4. 2014.7-2016.6,高抗逆性、高木糖转化工业酿酒酵母的选育及过程控制的研究,车用生物燃料技术国家重点实验室开放课题

5. 2013.1-2015.12,万吨级纤维素乙醇生产关键技术研究及示范-4 国家能源局项目 NY20130402

6. 2010.1-2012.12,相关代谢关键酶控制强化对木糖代谢酿酒酵母工程菌影响的研究,国家自然基金面上项目30970091

7. 2010.6-2012.12,酿酒酵母耐木质纤维素预处理原料毒性的机理研究,山东大学自主创新项目 

研究成果

1. 期刊论文(上标1代表共同第一作者,上标*为通讯作者)

(1) Wang, X., Liang, Z., Hou, J., Shen, Y.*, & Bao, X.*. (2017). The Absence of the Transcription Factor Yrr1p, Identified from Comparative Genome Profiling, Increased Vanillin Tolerance Due to Enhancements of ABC Transporters Expressing, rRNA Processing and Ribosome Biogenesis in Saccharomyces cerevisiae. Front Microbiol, 8, 367. doi: 10.3389/fmicb.2017.00367 (IF 4.165)

(2) Hou, J.1, Shen, Y.1, Jiao, C., Ge, R., Zhang, X., & Bao, X.*. (2016). Characterization and evolution of xylose isomerase screened from the bovine rumen metagenome in Saccharomyces cerevisiae. J Biosci Bioeng, 121(2), 160-165. doi: 10.1016/j.jbiosc.2015.05.014 (IF 1.964)

(3) Li, H.1, Shen, Y.1, Wu, M., Hou, J., Jiao, C., Li, Z., . . . Bao, X.*. (2016). Engineering a wild-type diploid Saccharomyces cerevisiae strain for second-generation bioethanol production. Bioresour Bioprocess, 3(1), 51. doi: 10.1186/s40643-016-0126-4 (新刊,虚拟IF 1.7)

(4) Wang, X., Liang, Z., Hou, J., Bao, X.*, & Shen, Y.*. (2016). Identification and functional evaluation of the reductases and dehydrogenases from Saccharomyces cerevisiae involved in vanillin resistance. BMC Biotechnol, 16(1), 31. doi: 10.1186/s12896-016-0264-y (IF 2.452)

(5) Li, H., Wu, M., Xu, L., Hou, J., Guo, T., Bao, X., & Shen, Y.*. (2015). Evaluation of industrial Saccharomyces cerevisiae strains as the chassis cell for second-generation bioethanol production. Microb Biotechnol, 8(2), 266-274. doi: 10.1111/1751-7915.12245 (IF 3.991)

(6) Wang, C., Bao, X., Li, Y., Jiao, C., Hou, J., Zhang, Q., . . . Shen, Y.*. (2015a). Cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization. Metab Eng, 30, 79-88. doi: 10.1016/j.ymben.2015.04.007 (IF 8.201)

(7) Wang, C., Bao, X., Li, Y., Jiao, C., Hou, J., Zhang, Q., . . . Shen, Y.*. (2015b). Data set for cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization. Data Brief, 4, 119-126. doi: 10.1016/j.dib.2015.05.005

(8) Shen, Y., Li, H., Wang, X., Zhang, X., Hou, J., Wang, L., . . . Bao, X*. (2014). High vanillin tolerance of an evolved Saccharomyces cerevisiae strain owing to its enhanced vanillin reduction and antioxidative capacity. J Ind Microbiol Biotechnol, 41(11), 1637-1645. doi: 10.1007/s10295-014-1515-3 (IF 2.81)

(9) Xu, L.1, Shen, Y.1 , Hou, J. , Tang, H., Wang, C., & Bao, X*. (2014). Promotion of extracellular activity of cellobiohydrolase I from Trichoderma reesei by protein glycosylation engineering in Saccharomyces cerevisiae. Curr Synthetic Sys Biol 2(2), 1-6. doi: 10.4172/2332-0737.1000111

(10) 吴宏宇, 吴显伟, 赵建志, 鲍晓明, 侯进, 王林风, . . . 沈煜*. (2014). 蛋白质质量控制系统在增强酿酒酵母耐热性中的作用及机制. 生物过程, 4, 7.

(11) Shen, Y., Hou, J., & Bao, X*. (2013). Enhanced xylose fermentation capacity related to an altered glucose sensing and repression network in a recombinant Saccharomyces cerevisiae. Bioengineered, 4(6), 435-437. doi: 10.4161/bioe.25542 (IF 1.87)

(12) Wang, C.1, Shen, Y.1, Hou, J., Suo, F., & Bao, X*. (2013). An assay for functional xylose transporters in Saccharomyces cerevisiae. Anal Biochem, 442(2), 241-248. doi: 10.1016/j.ab.2013.07.041 (IF 2.243)

(13) Peng, B.1, Shen, Y.1, Li, X., Chen, X., Hou, J., & Bao, X*. (2012). Improvement of xylose fermentation in respiratory-deficient xylose-fermenting Saccharomyces cerevisiae. Metab Eng, 14(1), 9-18. doi: 10.1016/j.ymben.2011.12.001 (IF 8.201)

(14) Shen, Y.1, Chen, X.1, Peng, B., Chen, L., Hou, J., & Bao, X*. (2012). An efficient xylose-fermenting recombinant Saccharomyces cerevisiae strain obtained through adaptive evolution and its global transcription profile. Appl Microbiol Biotechnol, 96(4), 1079-1091. doi: 10.1007/s00253-012-4418-0 (IF 3.42)

(15) Ji, L.1, Shen, Y.1, Xu, L., Peng, B., Xiao, Y., & Bao, X*. (2011). Enhanced resistance of Saccharomyces cerevisiae to vanillin by expression of lacA from Trametes sp. AH28-2. Bioresour Technol, 102(17), 8105-8109. doi: 10.1016/j.biortech.2011.06.057 (IF 5.651)

(16) 彭炳银, 陈晓, 沈煜*, & 鲍晓明. (2011). 不同启动子控制下木酮糖激酶的差异表达及其对酿酒酵母木糖代谢的影响. 微生物学报, 51(7) :914-922.

(17) Shen, Y., Zhang, Y., Ma, T., Bao, X.*, Du, F., Zhuang, G., & Qu, Y. (2008). Simultaneous saccharification and fermentation of acid-pretreated corncobs with a recombinant Saccharomyces cerevisiae expressing beta-glucosidase. Bioresour Technol, 99(11), 5099-5103. doi: 10.1016/j.biortech.2007.09.046 (IF 5.651)

2. 参编专著

(1) 曲音波,鲍晓明,陈冠军,方诩,高培基,刘巍峰,沈煜,汪天虹,王禄山,赵建,《木质纤维素降解酶与生物炼制》,化学工业出版社,ISBN 978-7-122-11311-520119

(2) 姜岷 曲音波 等,《非粮生物质炼制技术——木质纤维素生物炼制原理与技术》,化学工业出版社,ISBN 978-7-122-28373-3, 20182 

3. 部分授权发明专利

(1) 鲍晓明,沈煜,葛瑞蕾,A xylose isomerase and its encoding nucleic acid sequence2016.03.16,欧盟(进入英法德),EP 2679686 B1(已许可转让)

(2) 鲍晓明,沈煜,葛瑞蕾,A xylose isomerase and its encoding nucleic acid sequence2013.11.19,美国,US 8586336 B2(已许可转让)

(3) 沈煜,鲍晓明,霍文严,刘怀伟,一株能够代谢木糖的酿酒酵母菌株,2013.01.15,中国,CN201210088133.X

(4) 鲍晓明,沈煜,葛瑞蕾,一种编码木糖异构酶的核酸分子及其编码的木糖异构酶,2012.10.10,中国,CN201110042170.2(已许可转让)

 

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