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微生物学

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肖敏

0531-88365128 minxiao@sdu.edu.cn

教育背景:

起止时间 毕业院校 专业

博士 1996.9-2000.6 山东大学 微生物学

硕士 1985.9-1988.6 山东大学 微生物学

本科 1981.9-1985.9 山东大学 微生物学


工作经历:

2001-今 教授,博士生导师, 山东大学 微生物技术国家重点实验室&国家糖工程技术研究中心

1996-2000 副教授, 山东大学 微生物技术国家重点实验室

1988-1995 助教及讲师, 山东大学微生物系

2003 美国Wayne State Univ访问学者

1997-1998 日本京都大学(Kyoto Univ)UNESCO微生物学高级研修


科研方向:

主要集中在生物催化与生物合成方面,现今重点开展酶催化的糖基化作用研,也同时关注真菌的尼古丁代谢及光合细菌的类胡萝卜素合成研究。  


主持课题:

1. 国家自然基金项目“分子进化α-L-鼠李糖苷酶及酶法合成抗肿瘤药物的鼠李糖苷研究”(31670062)

2. 国家重点基础研究发展计划(973计划)“肿瘤的糖化学生物学前沿研究”课题2糖链探针的生物合成研究(2012CB822102)

3. 国家自然基金项目“米曲霉降解尼古丁的代谢途径、酶及其基因研究”(31170054)

4. 国家自然基金项目“分子改造Levan蔗糖酶拓展转糖基底物特异性研究”(31070064)

5. 国家自然基金项目“固氮红细菌类胡萝卜素代谢途径及其八氢番茄红素脱氢酶催化机制研究”(30970028)

6. 国家自然基金项目“具有转糖基活性的-半乳糖苷酶的分子改造”(30770065).

7. 国家863项目“分子改造糖苷酶转糖苷法制备低聚半乳糖技术”(2006AA10Z338)

8. 国家自然科学基金项目 “双歧杆菌-D-半乳糖苷酶转糖基作用的区域选择性研究”(30170008)


部分发表论文 (2014-2016)

1. Xiaodi Chen, Li Xu, Lan Jin, Bin Sun, Guofeng Gu, Lili Lu*, Min Xiao*.Efficient and regioselective synthesis of β-GalNAc/GlcNAc-lactose by a bifunctional transglycosylating β-N-acetylhexosaminidase from Bifidobacterium bifidum. Appl Environ Microbiol. 2016, 82(18):5642-5652.

2. Li Xu, Xiaohong Liu, Zhenhao Yin, Qian Liu, Lili Lu, Min Xiao *.Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design. Appl Microbiol Biotechnol. 2016, 100(24):10385-10394.

3. Wei Gong,Li Xu,Guofeng Gu,Lili Lu,Min Xiao*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis. Appl Microbiol Biotechnol 2016,100: 6693–6702.

4. Lijuan Xu, Tingting Qi, Li Xu, Lili Lu* & Min Xiao*. Recent progress in the enzymatic glycosylation of phenolic compounds. Journal of Carbohydrate Chemistry. 2016, 35(1):1-23.

5. Jie Zhang, Lili Lu, Li Lu, Yang Zhao, Liping Kang, Xu Pang, Jingyuan Liu, Tengchuan Jiang, Min Xiao*, Baiping Ma*. Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricus L3. Glycoconj J. Glycoconj J. 2016, 33(1):53-62.

6. Shuquan Fan, Huaqin Zhang, Xiaodi Chen, Lili Lu, Li Xu and Min Xiao*. Cloning, characterization, and production of three -L-fucosidases from Clostridium perfringens ATCC 13124. J Basic Microbiol. 2015, 55(4), 347-357.

7. Lili Lu, Qian Liu, Lan Jan, Zhenghao Yin, Li Xu, Min Xiao*. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis. PLoS One. 2015, 10(10):e0140531.

8. Lili Lu, Yuchuan Guo, Lijuan Xu, Tingting Qi, Lan Jin, Li Xu, Min Xiao*. Galactosylation of caffeic acid by an engineered β-galactosidase. Drug Discoveries & Therapeutics. 2015; 9(2):123-128.

9. Lili Lu, Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu, Min Xiao*. Glycosylation of Phenolic Compounds by the Site-Mutated β-Galactosidase from Lactobacillus bulgaricus L3. PLoS ONE. 2015, 10(3): e0121445.

10. Lili Zhang, Lili Lu, Shuquan Fan, Lan Jin, Guofeng Gu, Li Xu and Min Xiao*. One-step synthesis of -Gal epitope and globotriose derivatives by an engineered -galactosidase. RSC Advances, 2015, 5, 22361 – 22364.

11. Li Xu, Dongxue Wang, Lili Lu, Lan Jin, Jiawei Liu, Deyong Song, Zhongwu Guo, Min Xiao*. Purification, Cloning, Characterization, and N-Glycosylation Analysis of a Novel -Fructosidase from Aspergillus oryzae FS4 Synthesizing Levan- and Neolevan-Type Fructooligosaccharides. PLoS ONE. 2014, 9(12): e114793.

12. Lili Lu, Feng Fu, Renfei Zhao, Lan Jin, Chunjuan He, Li Xu, Min Xiao*. A recombinant levansucrase from Bacillus licheniformis 8-37-0-1catalyzes versatile transfructosylation reactions. Process Biochem. 2014, 49: 1503-1510.


授权发明专利:

ZL 2005 1 0044096.2 ZL 2010 1 0173646.1 ZL 2011 1 0119959.3

ZL 2005 1 0044097.7 ZL 2010 1 0220786.X ZL 2012 1 0156757.0

ZL 2005 1 0044897.9 ZL 2008 1 0139284.7 ZL 2013 1 0257432.6

ZL 2005 1 0044095.8 ZL 2010 1 0216912.4 ZL 2013 1 0121813.1

ZL 2005 1 0044898.3 ZL 2011 1 0190899.4 ZL 2013 1 0256580.6

ZL 2007 1 0015198.0 ZL 2011 1 0190960.5 ZL 2013 1 0257340.8

ZL 2008 1 0014906.3 ZL 2011 1 01909408.8 ZL 2013 1 0256401.9

ZL 2007 1 0116242.7 ZL 2011 1 0002979.2 ZL 2013 1 0257383.6

ZL 2008 1 0157830.X ZL 2010 1 0173582.5 ZL 2013 1 0255797.5



 

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