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微生物学

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庞秀华

86-531-88364590 pangxiuhua@sdu.edu.cn

工作及学习经历:

2009.3- 至今 :教授,博士生导师,山东大学

2004.3-2009.12:讲师(Instructor),高级研究助理(Research associate senior),博士后,University of Texas Health Science Center at Tyler, USA.

2001.5-2004.2:博士后,University of Nancy I,France.

1996.9-2000.7:博士,华中农业大学

1989.9-1992.7:硕士,中国科学院武汉病毒研究所

1985.9-1989.7:学士,山东师范大学


研究领域:

1. 链霉菌的基础生物学

2. 链霉菌的基因组挖掘

3. 具有新型结构及活性的次生代谢产物的分离和鉴定

4. 结核分枝杆菌的毒力因子及致病机制


主持课题:

1,国家自然科学基金面上项目(31470165),2015-01至2018-12

2,国家自然科学基金面上项目(81171540),2012-01至2015-12

3,国家自然科学基金面上项目(81071328),2011-01至2013-12

4,山东省自然科学基金面上项目(ZR2010HM007),2010-10至2013-10

5,山东大学自主创新基金(2012ZD031),2012-01至2014-12


部分发表论文:

*: 通讯作者;†:贡献等同

1. Zhao Z, Shi T, Xu M, Brock NL, Zhao YL, Wang Y, Deng Z, Pang X*, Tao M*. 2016. Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes. Organic LETTERS 18(3):572-5

2. Cao G, Howard ST, Zhang P, Wang X, Chen XL, Samten B, and Pang X*. 2015. EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR. Microbiology 161:477-489.

3. Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, and Pang X*. 2015. Production of the antibiotic FR-008/Candicidin in Streptomyces sp. FR-008 is coregulated by two regulators, FscRI and FscRIV, from different transcription factor families. Microbiology 161:539-552.

4. Zhang P, Wu H, Chen XL, Deng Z, Bai L, and Pang X*. 2014. Regulation of the Biosynthesis of Thiopeptide Antibiotic Cyclothiazomycin by a Transcriptiona1 Regulator SHJG8833 in Streptomyces hygroscopicus 5008. Microbiology 160:1379-1392.

5. Cao G, Howard ST, Zhang P, Hou G, and Pang X*. 2013. Functional analysis of the EspR binding sites upstream of espR in Mycobacterium tuberculosis. Current Microbiology 67:572-579.

6. Pang X*, Samten B, Cao G, Wang X, Tvinnereim A, Chen X, and Howard ST. 2013. MprAB regulates the espA operon in Mycobacterium tuberculosis, and modulates ESX-1 function and host cytokine response. Journal of Bacteriology 195:66-75.

7. Pang X, Howard ST. 2007. Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system of Mycobacterium tuberculosis. Journal of Bacteriology 189:6213-21.

8. Pang X, Vu P, Byrd TF, Ghanny S, Soteropoulos P, Mukamolova GV, 5.Wu S, Samten B, Howard ST. 2007. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology 153:1229-42.

9. Aigle B†, Pang X†, Decaris B, Leblond P. 2005. Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the dupliated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens. Journal of Bacteriology 187:2491-500.

10. Pang X, Aigle B, Girardet JM, Mangenot S, Pernodet JL, Decaris B, Leblond P. 2004. Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome. Antimicrob Agents Chemother 48:575-88.

11. Pang X, Zhou X, Sun Y, Deng Z. 2002. Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions. Journal of Bacteriology 184:1958-65.


 

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