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微生物学

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卞小莹

bianxiaoying@sdu.edu.cn
EDUCATION
Ph.D  Saarland University, Germany 2013
Master  Northwest A & F University, China 2008
Bachelor  Northwest A & F University, China 2005
WORK EXPERIENCE
2015.07-present, ‘Qilu Young Scholar’ Professor, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, China
2014.10-2015.06, research fellow, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, China
2012.10-2014.09, postdoctoral fellow, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany
RESEARCH INTERESTS
1.Biosynthesis, heterologous expression, engineering of microbial natural products
2.Genome mining for novel natural products
3.Synthetic biology and Recombineering
RESEARCH PROGRAMS
1.A chassis for heterologous expression of myxobacterial natural products: optimization and application
2.Elucidation and heterologous expression of chuangxinmycin biosynthetic pathway
3.Recombineering for bacterial natural product research
SELECTED PUBLICATIONS
1.Bian, X.; Plaza, A.; Zhang, Y.; Müller, R. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety. Chemical Science 6(5): 3154-3160, 2015
2.Bian, X.; Plaza, A.; Yan, F.; Zhang, Y.; Müller, R. Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo. Biotechnology and Bioengineering 112(7): 1343-1353, 2015
3.Bian, X.; Klefisch, T.; Huang, F.; Wang, H.; Müller, R.; Stewart, A.F.; Zhang, Y. Heterologous Production of Glidobactins/Luminmycins in Escherichia coli Nissle Expressing Glidobactin Biosynthetic Gene Cluster from Burkholderia DSM7029. ChemBioChem. 15(15): 2221-2224, 2014
4.Bian, X.; Fu, J.; Plaza, A.; Herrmann, J.; Pistorius, D.; Stewart, A.F.; Zhang, Y.; Müller, R. In vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation. ChemBioChem 14(10): 1194-1197, 2013
5.Ongley, SE #; Bian, X. #; Neilan, B.A.; Müller, R. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. Natural Product Reports 30(8): 1121-1138, 2013
6.Bian, X.; Plaza, A.; Zhang, Y.; Müller, R. Luminmycins A-C, Cryptic Natural Products from Photorhabdus luminescens Identified by Heterologous Expression in Escherichia coli. Journal of Natural Products 75(9):1652-1655, 2012
7.Bian, X.; Huang, F.; Stewart, F. A.; Xia, L.; Zhang, Y.; Müller, R. Direct Cloning, Genetic Engineering, and Heterologous Expression of the Syringolin Biosynthetic Gene Cluster in E. coli through Red/ET Recombineering. ChemBioChem. 13(13): 1946-1952, 2012
8.Fu J. #; Bian X.# Hu, S.; Wang, H.; Huang, F.; Seibert, PM.; Plaza, A.; Xia, L.; Müller, R.; Stewart, A.F.; Zhang, Y. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nature Biotechnology 40(5): 440-446, 2012.
PATENTS
1.Y. Zhang, J. Fu, X. Bian, F. Stewart, R. Müller. Heterologous hosts. US Patent App. 13/516,758, 2013
AWARDS
1.2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products (The American Society of Pharmacognosy)
2.2013 DECHMA travel grant for 1st European Conference on Natural Products
3.HZI 'Paper of the month’ - July 2012 (Helmholtz Centre for Infection Research)
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