Lijun Feng-School of Life Sciences Shandong University

One of my interests is in the mouse models, pearl and pale ear, for HERMANSKY-PUDLAK SYNDROME (HPS). Besides of classical phenotypes, these mouse mutants bear reduced fertility in both male and females. The female pearl mouse may serve as a model for infantile uterus which is one of the major reasons for female infertility.

Another interest of my research is the sex maturation and gamete formation. With the advanced CAS9 technology, we already mutated several genes in zebrafish which will be great models for us to study the detailed regulation mechanisms and provide new insights for human infertility.

TEACHING DUTIES:

1. Cell Biology and Cell Biology Lab for sophomore students

2. Methodology in Life Sciences Research for junior students

3. Seminar for graduate students

GRADUATED FROM MY LAB:

Since 2009, 8 Ph.D. and 18 Master students have graduated from my lab and I am proud of them.

PUBLICATIONS:

1. Zebrafish intelectin 1 (zITLN1) plays a role in the innate immune response. Chen L, Yan J, Shi J, Sun W, Chen Z, Yu J, Qi J, Du Y, Zhang H, Feng L*. Fish Shellfish Immunol. 2018 Dec;83:96-103. doi: 10.1016/j.fsi.2018.09.004. Epub 2018 Sep 6.

2. The D5 region of the intelectin domain is a new type of carbohydrate recognition domain in the intelectin gene family. Yan J, Chen L, Liu Z, Chen Y, Sun Y, Han J, Feng L. Dev Comp Immunol. 2018 Aug;85:150-160. doi: 10.1016/j.dci.2018.02.021. Epub 2018 Apr

3. A zebrafish intelectin ortholog agglutinates both Gram-negative and Gram-positive bacteria with binding capacity to bacterial polysaccharide. Chen L, Yan J, Sun W, Zhang Y, Sui C, Qi J, Du Y, Feng L. Fish Shellfish Immunol. 2016 Aug;55:729-36. doi: 10.1016/j.fsi.2016.06.023. Epub 2016 Jun 18.

4. The Ap3b1 gene regulates the ocular melanosome biogenesis and tyrosinase distribution differently from the Hps1 gene. Jing R*, Dong X, Li K, Yan J, Chen X, Feng L*. Exp Eye Res. 2014 Nov;128:57-66. doi: 10.1016/j.exer.2014.08.010. Epub 2014 Aug 24.

5. Two distinct phenotypes in pigmented cells of different embryonic origins in eyes of pale ear mice. Jing R, Dong X, Li K, Zhang J, Yan J, Feng L*. Exp Eye Res. 2014 Feb;119:35-43. doi: 10.1016/j.exer.2013.12.007. Epub 2013 Dec 17

6. Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution. Yan J*, Xu L, Zhang Y, Zhang C, Zhang C, Zhao F, Feng L*. Dev Comp Immunol. 2013 Oct;41(2):189-99. doi: 10.1016/j.dci.2013.04.016. Epub 2013 Apr 30.

7. Identification and primary immune characteristics of an amphioxus akirin homolog. Yan J, Dong X, Kong Y, Zhang Y, Jing R, Feng L*. Fish Shellfish Immunol. 2013 Aug;35(2):564-71. doi: 10.1016/j.fsi.2013.05.020. Epub 2013 May 31.

8. Characterization and comparative analyses of two amphioxus intelectins involved in the innate immune response. Yan J, Zhang C, Zhang Y, Li K, Xu L, Guo L, Kong Y, Feng L*. Fish Shellfish Immunol. 2013 May;34(5):1139-46. doi: 10.1016/j.fsi.2013.01.017. Epub 2013 Feb 18.

9. Identification of an amphioxus intelectin homolog that preferably agglutinates gram-positive over gram-negative bacteria likely due to different binding capacity to LPS and PGN. Yan J, Wang J, Zhao Y, Zhang J, Bai C, Zhang C, Zhang C, Li K, Zhang H, Du X, Feng L*. Fish Shellfish Immunol. 2012 Jul;33(1):11-20. doi: 10.1016/j.fsi.2012.03.023. Epub 2012 Mar 24.

10. Identification and characterization of an amphioxus matrix metalloproteinase homolog BbMMPL2 responding to bacteria challenge. Zhang Y, Zhang H, Kong Y, Feng L*. Dev Comp Immunol. 2012 Jul;37(3-4):371-80. doi: 10.1016/j.dci.2012.02.015. Epub 2012 Mar 19.

11. Evaluation of the cytotoxicity of a two photon absorbing fluorescence compound on human HepG2 cells and its application to tracking human hepatic cancer cells in mice. Du XM, Yan Y, Bai ZL*, Zhang JP, Wang Z, Liu LL, Feng LJ*. Biotech Histochem. 2010 Apr;85(2):107-13. doi:10.1080/10520290903149588

12. Phylogenetic analysis and expression pattern of the AmphiCaBP-like gene from amphioxus, encoding a novel member of the calmodulin-like subfamily. Li B, Lin Y, Zhang W, Shao M, Bian Y, Huang S, Feng L*, Zhang H*. DNA Seq. 2007 Jun;18(3):228-34.

Past publications searched in 2006/11:

1. Feng LJ, Arvan P

The trafficking of alpha(1)-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cells.

JOURNAL OF BIOLOGICAL CHEMISTRY 278 (34): 31486-31494 AUG 22 2003

SCI IF: 6.482 Times Cited: 9

2. Arvan P, Zhang BY, Feng LJ, et al.

Lumenal protein multimerization in the distal secretory pathway/secretory granules

CURRENT OPINION IN CELL BIOLOGY 14 (4): 448-453 AUG 2002

SCI IF: 19.022 Times Cited: 19

3. Feng LJ, Novak EK, Hartnell LM, et al.

The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes

BLOOD 99 (5): 1651-1658 MAR 1 2002

SCI IF: 9.273 Times Cited: 27

4. Swank RT, Novak EK, Feng LJ, et al. Abnormal vesicular trafficking in mouse models of Hermansky-Pudlak syndrome.

PIGMENT CELL RESEARCH 13: 59-67 Suppl. 8 2000.

SCI IF: 3.0 Times Cited: 39

5. Feng LJ, Rigatti BW, Novak EK, et al.

Genomic structure of the mouse Ap3b1 gene in normal and pearl mice

GENOMICS 69 (3): 370-379 NOV 1 2000

SCI IF: 3.425 Times Cited: 76

6. Feng LJ, Zhen LJ, Jiang S, et al.

Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse

BLOOD 94 (1): 146-155 JUL 1 1999

SCI IF: 8.372 Times Cited: 39

7. Feng LJ, Seymour AB, Jiang S, et al.

The beta 3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness

HUMAN MOLECULAR GENETICS 8 (2): 323-330 FEB 1999

SCI IF: 9.307 Times Cited: 126

8. Swank RT, Novak EK, Feng LJ, et al.

Mouse models of Hermansky Pudlak Syndrome: A review

PIGMENT CELL RESEARCH 11 (2): 60-80 APR 1998

SCI IF: 3.0 Times Cited: 121

8Genome Conference. 1997.

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