EDUCATION 

Ph.D  1996-2001 Zhejiang University   Plant Nutrition

B.S. 1990-1994  Shandong University  Biology

WORK EXPERIENCE

2014.9-present Shandong University School of Life Sciences Assoicate Professor

2008.10-2014.8 Shandong University School of Life Sciences  Instructor

2004. 2-2008.9 Emory University Winship Cancer Institute  Res. Speicalist Lead

2001.9-2004.2 China Science & Technology Museum  Engineer

RESEARCH INTERST

1. Cancer metastasis

2. Anti-cancer compound screening and molecular therapeutics

AWARDS

1. Award of Teaching Master, Shandong University, 2012

2. Teaching Contest of Shandong University (Young Teachers), Second Award, 2012

SELECTED PUBLICATIOS

1. Yao S, Shi F, Wang Y, Sun X, Sun W, Zhang Y, Liu X, Liu X*, Su L*. Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells. Cellular Signalling. 2019;61:10-19.

2. An W, Yao S, Sun X, Hou Z, Lin Y*, Su L*, Liu X*. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019 May 2;38(1):181.

3. Li M, An W, Xu L, Lin Y, Su L*, Liu X*. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 2019 Feb 8;38(1):64.

4. Yu X#, Ling J#, Liu X, Guo S, Lin Y, Liu X, Su L*. Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells. Oncotarget. 2017 Jan 24;8(4):6691-6699.

5. Liu Z, Chu S, Yao S, Li Y, Fan S, Sun X, Su L*, Liu X*. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells. Oncotarget. 2016. Oct 18;7(42):68303-68313.

6. Zhang M#, Su L#, Xiao Z, Liu X, Liu X*. Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer. Am J Cancer Res. 2016; 6(2):187-99.

7. Liu X, Guo S, Liu X, Su L*. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. Apoptosis. 2015; 20(11):1499-507.

8. Li T#, Su L#, Lei Y#, Liu X, Zhang Y, Liu X*. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015; 290:11108-18.

9. Cui J, Sun W, Hao X, Wei M, Su X, Zhang Y, Su L, Liu X*. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int. 2015; 15(1):4.  

10. Yan J, Zhong N, Liu G, Chen K, Liu X, Su L*, Singhal S. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014; 5: e1316.

11. Zhao X, Liu X, Su L*(苏玲). Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014; 33(1):3.

12. Liu X, Su L*(苏玲), Liu X. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells. FEBS Lett. 2013; 587: 3995-4000.

13. Li T, Su L(co-first author) (苏玲), Zhong N, Hao X, Zhong D, Singhal S, Liu X. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9(7):1057-1068.

14. Yang L, Su L(co-first author) (苏玲), Cao C, Xu L, Zhong D, Xu L, Liu X. The chalcone 2'-hydroxy- 4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells. IUBMB Life. 2013; 65:533-43.

15. Xu L, Su L(co-first author) (苏玲), Liu X. PKCδ regulates death receptor 5 expression induced by PS-341 through ATF4-ATF3/CHOP axis in human lung cancer cells. Mol Cancer Ther. 2012; 11:2174-82.

16. Liu G, Su L* (co-first author) (苏玲), Hao X, Zhong N, ZHong D, Singhal S, Liu X*. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012; 16:1618-28.

17. Wang Q, Sun W, Hao X, Li T, Su L* (苏玲), Liu X. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells. Cancer Cell Int. 2012; 12(1):54.

18. Jia G, Su L(苏玲), Singhal S, Liu X. Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging. Mol Cell Biochem. 2012;364(1):345-50.