王勐骋教授

电 话：0532-58630886， E-Mail：wangmc@sdu.edu.cn

个人简介

1998年南京大学本科毕业，2004年南京大学博士毕业。2004年起在山东大学从事博士后研究，其后在山东大学工作。主要从事小麦抗旱耐盐遗传基础、分子机制和种质创制研究。近年来在Nature Communications、Plant Physiology、Plant Journal和Molecular & Cellular Proteomics等杂志发表多篇论文。

教学

主讲《细胞生物学》专业基础课及《细胞遗传学》和《实验数据分析与软件操作》等选修课。先后获得山东大学青年教师讲课比赛优秀奖和生命科学学院青年教师讲课比赛一等奖，指导硕士生获得山东大学优秀硕士生毕业论文。

科研方向

1.小麦抗旱耐盐分子机制及功能基因研究

结合正向遗传学和反向遗传学等技术手段，利用小麦自然群体和突变体，解析小麦抗旱耐盐的遗传基础，克隆小麦抗旱耐盐重要基因，阐明其分子机制和调控网络，鉴定抗旱耐盐重要基因的优异等位变异，为小麦抗旱耐盐分子设计提供分子标记和编辑靶点，创制小麦抗旱耐盐新种质。

2.小麦抗旱小分子作用机制和化学农业应用

次生代谢产物合成的改变是应对环境胁迫的生理基础之一。课题组结合分子生物学和代谢组学等方法，鉴定小麦抗旱相关小分子化合物，解析其抗旱分子调控机制，并通过大田试验筛选能提高水分利用效率和节水产量的小分子化合物，应用于化学农业。

小麦抗旱GWAS分析

小麦抗旱基因TaWD40-4B.1抗旱机制

近年来主持课题

1. 2023-2027，小麦响应水分胁迫的遗传与分子调控网络，国家重点研发计划

2. 2022-2024，小麦抗旱重要基因鉴定、调控网络构建和新种质创制，山东省自然科学基因重点项目

3. 2022-2025，黄酮醇通过TaSnRK2调控小麦盐胁迫下种子萌发的功能和机制分析，国家自然科学基因面上项目

4. 2019-2022，小麦TaGBF1-TaCKB4通路协调蓝光和盐胁迫应答信号交互的分子机制研究，国家自然科学基因面上项目

5. 2020-2020，小麦重要耐盐碱抗旱节水基因功能分析和分子育种，国家重大转基因专项

6. 2018-2020，小麦干旱应答类黄酮代谢组和功能差异及其分子育种研究，山东省重点研发计划

7. 2016-2020，主要农作物细胞工程育种新方法与应用，国家重大研发计划子课题

8. 2016-2020，抗逆转基因小麦新品种培育，国家重大转基因专项子课题

9. 2016-2019，黄酮醇在盐胁迫应答中的功能及其生物合成的应答调控机制研究，国家自然科学基金面上项目

发表论文

一、第一和通讯作者文章

1. Tian G, Wang, S, Wu J, Wang Y, Wang X, Liu S, Han D, Xia G *, Wang M *. Allelic variation of TaWD40-4B.1 contributes to drought tolerance by modulating catalase activity in wheat. Nature Communications, 2023, 14: 1200.

2. Xiao G, Zhao M, Liu Q, Zhou J, Wang Q, Cheng Z, Xia G, Wang M *. TaBAS1 encoding a typical 2-Cys peroxiredoxin enhances salt tolerance in wheat. Frontiers in Plant Science, 2023, 14: 1152375.

3. Xu W, Li Y, Li Y, Liu C, Wang Y, Xia G, Wang M *. Asymmetric Somatic Hybridization Affects Synonymous Codon Usage Bias in Wheat. Frontiers in Genetics, 2021, 12: 682324.

4. Xiao G, Zhou J, Huo Z, Wu T, Li Y, Li Y, Wang Y, Wang M *. The Shift in Synonymous Codon Usage Reveals Similar Genomic Variation during Domestication of Asian and African Rice. International Journal of Molecular Sciences, 2022, 23: 12860.

5. Xu W, Li Y, Li Y, Liu C, Wang Y, Xia G, Wang M *: Asymmetric somatic hybridization affects synonymous codon usage bias in wheat. Frontiers in Genetics, 2021: 682324.

6. Wang Y, Liu Q, Liu Y, Li G, Xia G, Wang M *: Ectopic expression of a wheat superoxide dismutase gene TaSOD5 enhances salt and oxidative stress tolerance in Arabidopsis. Biologia Plantarum, 2021, 65: 19-26.

7. Tian G, Li G, Liu Y, Liu Q, Wang Y, Xia G, Wang M *: Polyploidization is accompanied by synonymous codon usage bias in the chloroplast genomes of both cotton and wheat. Plos One, 2020, 15: e0242624.

8. Lv H, Cui X, Zhang P, Li Y, Ji Y, Wang Y, Xia G, Wang M *: Evaluating the role of wheat histone variant genes in development and response to abiotic stress in Arabidopsis. Biologia Plantarum, 2019, 63: 594-600.

9. Wang M *, Ji Y, Feng S, Liu C, Xiao Z, Wang X, Wang Y, Xia G *. The non-random patterns of genetic variation induced by asymmetric somatic hybridization in wheat. BMC Plant Biology, 2018, 18: 244.

10. Wang M *, Zhao X, Xiao Z, Yin X, Xing T, Xia G. A wheat superoxide dismutase gene TaSOD2 enhances salt resistance through modulating redox homeostasis by promoting NADPH oxidase activity. Plant Molecular Biology 2016, 91:115-130.

11. Xu W, Lv H, Zhao M, Li Y, Qi Y, Peng Z, Xia G, Wang M *. Proteomic comparison reveals the contribution of chloroplast to salt tolerance of a wheat introgression line. Scientific Reports 2016, 6.

12. Xu W, Li Y, Cheng Z, Xia G, Wang M *. A wheat histone variant gene TaH2A.7 enhances drought tolerance and promotes stomatal closure in Arabidopsis. Plant Cell Reports 2016, 35:1853-1862.

13. Wang M *, Liu C, Xing T, Wang Y, Xia G. Asymmetric somatic hybridization induces point mutations and indels in wheat. BMC Genomics 2015, 16.

14. Xu W, Xing T, Zhao M, Yin X, Xia G, Wang M. Synonymous Codon Usage Bias in Plant Mitochondrial Genes Is Associated with Intron Number and Mirrors Species Evolution. Plos One 2015, 10.

15. Sun Y, Xu W, Jia Y, Wang M *, Xia G *. The wheat TaGBF1 gene is involved in the blue-light response and salt tolerance. Plant Journal 2015, 84:1219-1230. (并列通讯)

16. Qi Y, Xu W, Xing T, Zhao M, Li N, Yan L, Xia G, Wang M. Synonymous Codon Usage Bias in the Plastid Genome is Unrelated to Gene Structure and Shows Evolutionary Heterogeneity. Evolutionary Bioinformatics 2015, 11:65-77.

17. Dong W, Wang M, Xu F, Quan T, Peng K, Xiao L, Xia G. Wheat Oxophytodienoate Reductase Gene TaOPR1 Confers Salinity Tolerance via Enhancement of Abscisic Acid Signaling and Reactive Oxygen Species Scavenging. Plant Physiology 2013, 161:1217-1228. (并列一作)

18. Qin Z, Lv H, Zhu X, Meng C, Quan T, Wang M, Xia G. Ectopic Expression of a Wheat WRKY Transcription Factor Gene TaWRKY71-1 Results in Hyponastic Leaves in Arabidopsis thaliana. Plos One 2013, 8. (并列通讯)

19. Qin Z, Cai Z, Xia G, Wang M *. Synonymous codon usage bias is correlative to intron number and shows disequilibrium among exons in plants. BMC Genomics 2013, 14.

20. Qin Y, Wang M *, Tian Y, He W, Han L, Xia G. Over-expression of TaMYB33 encoding a novel wheat MYB transcription factor increases salt and drought tolerance in Arabidopsis. Molecular Biology Reports 2012, 39:7183-7192. (并列一作)

21. Liu C, Li S, Wang M *, Xia G. A transcriptomic analysis reveals the nature of salinity tolerance of a wheat introgression line. Plant Molecular Biology 2012, 78:159-169. (并列一作)

22. Zhao X, Wang M *, Quan T, Xia G: The role of TaCHP in salt stress responsive pathways. Plant Signaling & Behavior 2012, 7:71-74. (并列一作)

23. Dong W, Lv H, Xia G, Wang M *. Does diacylglycerol serve as a signaling molecule in plants? Plant Signaling & Behavior 2012, 7:472-475.

24. Peng Z, Wang M *, Li F, Lv H, Li C, Xia G. A Proteomic Study of the Response to Salinity and Drought Stress in an Introgression Strain of Bread Wheat. Molecular & Cellular Proteomics 2009, 8:2676-2686. (并列一作)

25. Wang M *, Peng Z, Li C, Li F, Liu C, Xia G. Proteomic analysis on a high salt tolerance introgression strain of Triticum aestivum/Thinopyrum ponticum. Proteomics 2008, 8:1470-1489.

26. Wang M *, Liu Y, Wang Q, Gong M, Hua X, Pang Y, Hu S, Yang Y. Impacts of methamidophos on the biochemical, catabolic, and genetic characteristics of soil microbial communities. Soil Biology & Biochemistry 2008, 40:778-788.

27. Wang M *, Gong M, Zang H, Hua X, Yao J, Pang Y, Yang Y. Effect of methamidophos and urea application on microbial communities in soils as determined by microbial biomass and community level physiological profiles. Journal of Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes 2006, 41:399-413.

28. Wang M *, Yang Y, Zang H. Effects of methamidophos on soil microbial communities measured by PLFA, CLPPs and ARDRA markers. Shengtaixue Zazhi 2006, 25:640-645.

二、非第一或通讯作者论文

1. Zhao Y, Ai X, Wang M, Xiao L, Xia G: A putative pyruvate transporter TaBASS2 positively regulates salinity tolerance in wheat via modulation of ABI4 expression. BMC Plant Biology 2016, 16.

2. Zhao Y, Dong W, Zhang N, Ai X, Wang M, Huang Z, Xiao L, Xia G: A Wheat Allene Oxide Cyclase Gene Enhances Salinity Tolerance via Jasmonate Signaling. Plant Physiology 2014, 164:1068-1076.

3. He Y, Li W, Lv J, Jia Y, Wang M, Xia G: Ectopic expression of a wheat MYB transcription factor gene, TaMYB73, improves salinity stress tolerance in Arabidopsis thaliana. Journal of Experimental Botany 2012, 63:1511-1522.

4. Wang MQ, Peng ZY, Wang MC, Guo W, Zhao JS, Zhi DY, Xia GM: The Behavior of Bupleurum scorzonerifolium as a Parent of Somatic Hybrid Introgressed Lines Is Associated with UV Resistance of Its Chromosomes. Russian Journal of Plant Physiology 2011, 58:615-621.

5. Li C, Lv J, Zhao X, Ai X, Zhu X, Wang M, Zhao S, Xia G: TaCHP: A Wheat Zinc Finger Protein Gene Down-Regulated by Abscisic Acid and Salinity Stress Plays a Positive Role in Stress Tolerance. Plant Physiology 2010, 154:211-221.

6. Han X, Wang R, Liu R, Wang M, Zhou J, Guo W: Effects of vegetation type on soil microbial community structure and catabolic diversity assessed by polyphasic methods in North China. Journal of Environmental Sciences 2007, 19:1228-1234.

7. Han X, Guo W, Wang R, Wang M: Microbial communities in microcosm soils treated with battery waste. Progress in Natural Science 2007, 17:919-926.

8. Yang Y, Yao J, Wang M: RAPD marker and substrate utilization pattern applied to study microbial community diversity in the soil affected by agricultural chemicals. Journal of Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes 2004, 39:125-138.

专利

1. AGENTS FOR IMPROVING WATER USE EFFICIENCY，2021，国际发明专利，PCT/CN2021/070500

2. 小麦耐盐基因TaPEX1及其应用，2018.9，200710459189.4

3. 小麦耐盐基因TaSOD2及其应用，2014.11，201410649749.9

4. 小麦盐敏基因TaDi19A及其应用，2011.03，200910014350.2

5. 小麦应答非生物胁迫抗性基因TaCEO及其应用，2011.05，200910019643.X