苏玲 副教授 

电话：0532-58630878

E-mail: suling@sdu.edu.cn

学术网页

https://www.researchgate.net/profile/Ling-Su-6

教育经历

1996/09-2001/07 浙江大学，环境资源学院，博士

1992/09-1996/07 山东大学，生命科学学院，学士

工作经历

2008/08-现在，   山东大学，生命科学学院，副教授，硕导

2004/02-2008/08，美国Emory大学医学院Winship癌症研究所2001/09-2004/02，中国科学技术馆实验教育部，工程师

研究方向

1.肿瘤细胞死亡及转移调控机制

2.肿瘤免疫机制

3.先进生物医药技术开发

荣誉和奖励

2012，山东大学第六届教学能手

2012，山东大学青年教师讲课比赛二等奖

2011，中国细胞生物学会青年教师讲课比赛三等奖

2009，山东大学生命科学学院青年教师讲课比赛一等奖

代表性论文

1.Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L*, Liu X*. Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells. Cell Death Dis. 2023;14(9):645.

2.Wang Y, Wei M, Su M, Du Z, Dong J, Zhang Y, Wu Y, Li X, Su L*, Liu X*. DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells. iScience, 2023; 26(7):107157.

3.Xu L, Shi F, Wu Y, Yao S, Wang Y, Jiang X, Su L*, Liu X*. Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells. Cell Commun Signal. 2023;21(1):83.

4.Yao S, Shi F, Mu N, Li X,Ma G,Wang Y, Sun X, Liu X*, Su L*. Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. Cancer Lett. 2021; 502:1-8.

5.Li X, Ma G, Guo W, Mu N, Wang Y, Liu X, Su L*.Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells.Cell Commun Signal. 2021;19(1):80.

6.Wang Y, Sun Q, Mu N, Sun X, Wang Y, Fan S, Su L*, Liu X*.The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells. Cell Commun Signal. 2020;18(1):112.

7.Wang Y, Guo S, Li D, Tang Y, Su L*, Liu X*. YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells. Cell Death Dis. 2020; 11(4):242.

8.Mu N, Lei Y, Wang Y, Wang Y, Duan Q, Ma G, Liu X*, Su L*. Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. Apoptosis. 2019 2019 Oct; 24(9-10):798-811.

9.An W, Yao S, Sun X, Hou Z, Lin Y*, Su L*, Liu X*. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019; 38(1):181.

10.Li M, An W, Xu L, Lin Y, Su L*, Liu X*. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 2019; 38(1):64.

11.Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X*. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015; 290:11108-18.

12.Liu X, Guo S, Liu X, Su L*. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. Apoptosis. 2015; 20(11):1499-507.

13.Zhao X, Liu X, Su L*. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014; 33(1):3.

14.Yan J, Zhong N, Liu G, Chen K, Liu X, Su L*, Singhal S. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014; 5: e1316.

15.Li T#, Su L#, Zhong N, Hao X, Zhong D, Singhal S, Liu X*. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9(7):1057-1068.

16.Liu X, Su L*, Liu X*. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells. FEBS Lett. 2013; 587:3995-4000.

17.Xu L#, Su L#, Liu X*. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells. Mol Cancer Ther. 2012; 11(10):2174-82.

18.Su L#, Liu G#, Hao X, Zhong N, Zhong D, Liu X*, Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer. 2011; 47(16):2471-8.

19.Wang D#, Su L# , Huang D, Zhang H, Shin DM, Chen ZG. Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of EGFR. Mol Cancer. 2011; 10:116.